Department of Physics and Complex Systems Group - PRISM, MSU-Iligan Institute of Technology, Tibanga, Iligan City, 9200, Philippines.
Department of Physics and Complex Systems Group - PRISM, MSU-Iligan Institute of Technology, Tibanga, Iligan City, 9200, Philippines.
Biochem Biophys Res Commun. 2021 Apr 23;550:171-176. doi: 10.1016/j.bbrc.2021.02.133. Epub 2021 Mar 17.
Recent results show that the chemotactic response of uni-cellular decentralized systems such as amoeboid and mammalian cells, is excitable. The same observation has not yet been reported for multi-nucleated decentralized biological systems. Here we present experimental results that shows the Physarum polycephalum plasmodial nodes spatio-temporal chemotactic dynamics as an excitable response. We found a highly optimized signal synthesis method wherein the Physarum nodes employ two intensity thresholds to properly navigate the chemoattractant field and generate corresponding spike dynamics in the node count. The node spike dynamics was found to correspond to the polarized-depolarized transition in the Physarum polycephalum morphology. Validation of our experimental observations via Brownian lattice simulations yields the same quantitative results with our experiments.
最近的研究结果表明，单细胞分散系统（如变形虫和哺乳动物细胞）的趋化反应是激活性的。多细胞核分散生物系统尚未有相同的观察结果。在这里，我们提出了实验结果，表明多头绒泡菌原生质团节点的时空趋化动力学是激活性的。我们发现了一种高度优化的信号合成方法，其中 Physarum 节点采用两个强度阈值来正确导航趋化场并在节点计数中产生相应的尖峰动力学。发现节点尖峰动力学与 Physarum polycephalum 形态中的极化-去极化转变相对应。通过布朗晶格模拟对我们的实验观察进行验证，得到了与实验相同的定量结果。
