Department of Otolaryngology-HNS, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Department of Otolaryngology-HNS, University of Michigan Medical School, 1904 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5321, USA.
Otolaryngol Clin North Am. 2021 Apr;54(2):281-294. doi: 10.1016/j.otc.2020.11.004.
Sentinel lymph node biopsy is the most precise and accurate staging technique for malignant melanoma. This resulted from international collaborations and technical innovations across subspecialties and systematic and methodical study of real-time clinical problems. This article describes sentinel node biopsy from conception to current techniques. Indications for the procedure and evidence of its prognostic value are discussed. Controversies surrounding results of Multicenter Selective Lymphadenectomy Trial I and II and German Dermatologic Cooperative Oncology Group Selective Lymphadenectomy trial are reviewed. Head and neck melanoma is presented as a unique subsite for performing sentinel node biopsy and when considering completion cervical lymphadenectomy.
前哨淋巴结活检是恶性黑色素瘤最精确和准确的分期技术。这是国际合作和跨专业技术创新的结果，也是对实时临床问题进行系统和有条理研究的结果。本文描述了从概念到当前技术的前哨淋巴结活检。讨论了该手术的适应证和其预后价值的证据。回顾了多中心选择性淋巴结切除术试验 I 和 II 以及德国皮肤病合作肿瘤学组选择性淋巴结切除术试验的结果争议。头颈部黑色素瘤是进行前哨淋巴结活检的独特部位，也是考虑完成颈部淋巴结清扫术的部位。
