Murphy S A, Caspary W J, Margolin B H
Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Mutat Res. 1988 Jun;203(3):145-54. doi: 10.1016/0165-1161(88)90100-8.
This paper illustrates the usefulness of solvent control trials and presents a statistical analysis for mouse L5178Y lymphoma data. Examination of solvent control trials establishes that the natural logarithm of mutant frequency is approximately normally distributed and that both the mean and variance of mutant frequency vary by trial. There is little evidence of downturns at higher doses in the dose-response curves studied; therefore, a trend test is proposed for the detection of an increasing dose-response curve. A Monte Carlo investigation confirms that the proposed trend test is better able to detect an increasing dose-response than 4 alternate methods of analysis.
本文阐述了溶剂对照试验的实用性，并对小鼠L5178Y淋巴瘤数据进行了统计分析。对溶剂对照试验的考察表明，突变频率的自然对数近似呈正态分布，且突变频率的均值和方差在不同试验中有所变化。在所研究的剂量反应曲线中，几乎没有证据表明在较高剂量时有下降趋势；因此，提出了一种趋势检验方法来检测剂量反应曲线的上升趋势。蒙特卡罗研究证实，所提出的趋势检验方法比其他4种分析方法更能检测出上升的剂量反应。
