School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Multidisciplinary Department of Medical-Surgical and Dental Specialties, Orthodontic Program, University of Campania Luigi Vanvitelli, Naples, Italy.
J Clin Sleep Med. 2021 Aug 1;17(8):1627-1634. doi: 10.5664/jcsm.9262.
To analyze differences in mandibular cortical width (MCW) among children diagnosed with obstructive sleep apnea (OSA) or at high- or low-risk for OSA.
A total of 161 children were assessed: 60 children with polysomnographically diagnosed OSA, 56 children presenting symptoms suggestive of high-risk for OSA, and 45 children at low risk for OSA. Children at high- and low-risk for OSA were evaluated through the Pediatric Sleep Questionnaire. MCW was calculated using ImageJ software from panoramic radiograph images available from all participants. Differences between MCW measurements in the 3 groups were evaluated using analysis of covariance and Bonferroni post-hoc tests, with age as a covariate. The association between MCW and specific cephalometric variables was assessed through regression analysis.
The participants' mean age was 9.6 ± 3.1 years (59% male and 41% female). The mean body mass index -score was 0.62 ± 1.3. The polysomnographically diagnosed OSA group presented smaller MCW than the group at low-risk for OSA (mean difference = -0.385 mm, = .001), but no difference with the group at high-risk for OSA (polysomnographically diagnosed OSA vs high-risk OSA: = .085). In addition, the MCW in the group at high-risk for the OSA was significantly smaller than the group at low-risk for the OSA (mean difference = -0.301 mm, = .014). The cephalometric variables (Sella-Nasion-A point angle (SNA) and Frankfort - Mandibular Plane angle (FMA)) explained only 8% of the variance in MCW.
Reductions in MCW appear to be present among children with OSA or those at high-risk for OSA, suggesting potential interactions between mandibular bone development and/or homeostasis and pediatric OSA.
Fernandes Fagundes NC, d'Apuzzo F, Perillo L, et al. Potential impact of pediatric obstructive sleep apnea on mandibular cortical width dimensions. . 2021;17(8):1627-1634.
分析诊断为阻塞性睡眠呼吸暂停（OSA）或有中高度 OSA 风险的儿童的下颌骨皮质宽度（MCW）差异。
共评估了 161 名儿童：60 名经多导睡眠图诊断为 OSA 的儿童，56 名有中高度 OSA 风险的症状提示的儿童，45 名低 OSA 风险的儿童。中高度 OSA 风险的儿童通过儿科睡眠问卷进行评估。MCW 使用所有参与者的全景放射图像，使用 ImageJ 软件计算。使用协方差分析和 Bonferroni 事后检验评估 3 组 MCW 测量值之间的差异，年龄为协变量。通过回归分析评估 MCW 与特定头影测量变量之间的关联。
参与者的平均年龄为 9.6 ± 3.1 岁（59%为男性，41%为女性）。平均体重指数 - 评分 0.62 ± 1.3。经多导睡眠图诊断为 OSA 的组的 MCW 小于低 OSA 风险组（平均差异 = -0.385 毫米， =.001），但与高 OSA 风险组无差异（经多导睡眠图诊断为 OSA 与高 OSA 风险： =.085）。此外，高 OSA 风险组的 MCW 明显小于低 OSA 风险组（平均差异 = -0.301 毫米， =.014）。头影测量变量（Sella-Nasion-A 点角（SNA）和法兰克福 - 下颌平面角（FMA））仅解释 MCW 方差的 8%。
OSA 儿童或高 OSA 风险儿童的 MCW 似乎减少，提示下颌骨发育和/或内稳态与儿科 OSA 之间可能存在相互作用。
Fernandes Fagundes NC, d'Apuzzo F, Perillo L, et al. 潜在影响儿科阻塞性睡眠呼吸暂停对下颌皮质宽度维度的影响。. 2021;17(8):1627-1634.
