Department of Congenital Heart Disease/Pediatric Cardiology, German Heart Center Berlin, Berlin, Germany; Department of Neonatology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Neonatology, Hospital Zollikerberg, Zollikerberg, Switzerland.
Department of Neonatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
J Cardiothorac Vasc Anesth. 2021 Oct;35(10):2900-2906. doi: 10.1053/j.jvca.2021.02.038. Epub 2021 Feb 17.
The authors aimed to assess whether untreated preoperative anemia was associated with increased risk for adverse outcomes after the arterial switch operation in neonates with dextro-transposition of the great arteries (d-TGA).
Retrospective cohort study.
Single cardiac surgery center.
Eighty-two newborns with d-TGA.
The authors categorized the cohort into the following two groups: the infants with preoperative anemia group (defined as a hematocrit <0.40 L/L) and the control group.
Preoperative anemia was diagnosed in 21 (25.6%) infants. Anemic infants received intraoperative red blood cell transfusions significantly more often than controls (81.0% v 34.4%, p < 0.001). No differences were observed in the incidence of adverse events, duration of hospitalization (median 27 days v 26 days, p = 0.881), and mortality (0% v 4.9%, p = 0.566). Postnatal hematocrit was the only variable independently associated with preoperative anemia in multivariate logistic regression analysis (unit odds ratio, 0.832; 95% confidence interval, 0.743-0.931; p = 0.001).
Untreated preoperative anemia was not associated with adverse outcomes in neonates undergoing reparative surgery for d-TGA.
本研究旨在评估未经治疗的术前贫血是否与右室型大动脉转位（d-TGA）新生儿动脉调转术后不良结局风险增加相关。
回顾性队列研究。
单一心血管外科中心。
82 名患有 d-TGA 的新生儿。
本研究将队列分为以下两组：术前贫血组（定义为血细胞比容＜0.40 L/L）和对照组。
21 名（25.6%）婴儿被诊断为术前贫血。贫血婴儿术中接受红细胞输血的比例明显高于对照组（81.0%比 34.4%，p＜0.001）。两组不良事件发生率、住院时间（中位数 27 天比 26 天，p=0.881）和死亡率（0%比 4.9%，p=0.566）均无差异。多变量逻辑回归分析显示，出生后血细胞比容是术前贫血的唯一独立相关变量（单位优势比，0.832；95%置信区间，0.743-0.931；p=0.001）。
未治疗的术前贫血与接受 d-TGA 修复手术的新生儿不良结局无关。
