Vahl J M, von Witzleben A, Reiter R, Theodoraki M N, Wigand M, Hoffmann T K, Goldberg-Bockhorn E
Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, 89075 Ulm, Germany.
Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, 89075 Ulm, Germany.
Explore (NY). 2022 May-Jun;18(3):366-370. doi: 10.1016/j.explore.2021.03.001. Epub 2021 Mar 9.
Researchers take different positions when describing the effects of infrasound on the human body. Although several studies investigated the likely harmful effects of infrasound exposure from wind turbines a significant connection has not been found yet. There is evidence that infrasound interacts with cell metabolism and may disrupt cell membrane integrity.
The suggested impairment of the cells' ultrastructure by infrasound leads to the question of whether infrasound can be therapeutically used, for instance in cancer therapy. This review provides the current state of the literature.
Current literature on infrasound in cancer therapy including all studies with the search terms 'cancer' and 'infrasound' were identified and reviewed until the year 2020.
The present state of research reveals promising effects of targeted infrasound in cancer therapy. Infrasound directly affects the tumor cells' ultrastructure and seems to sensitize several types of cancer to chemotherapy, presumably due to membrane permeabilization. The application of infrasound on tumor cells without other therapeutic agents demonstrates different effects that probably depend on the type of cells, the applied frequency and sound pressure level as well as the time of exposure.
The mechanism of infrasound on cancer cells is not completely understood yet, hence, further studies have to be conducted to clarify the ultrastructural and metabolic changes inside the tumor cells. The development of suitable infrasound generators for the application in a clinical setting would be an important course of action.
研究人员在描述次声对人体的影响时持不同立场。尽管有多项研究调查了风力涡轮机产生的次声暴露可能产生的有害影响，但尚未发现显著关联。有证据表明，次声与细胞代谢相互作用，可能会破坏细胞膜的完整性。
次声对细胞超微结构的潜在损害引发了一个问题，即次声是否可用于治疗，例如癌症治疗。本综述介绍了当前的文献状况。
检索并综述了截至2020年关于次声在癌症治疗方面的现有文献，包括所有使用“癌症”和“次声”作为检索词的研究。
目前的研究状况显示，靶向性次声在癌症治疗中具有显著效果。次声直接影响肿瘤细胞的超微结构，似乎能使多种类型的癌症对化疗更敏感，这可能是由于细胞膜通透性增加所致。在不使用其他治疗药物的情况下，对肿瘤细胞施加次声会产生不同的效果，这可能取决于细胞类型、施加的频率和声压水平以及暴露时间。
次声对癌细胞的作用机制尚未完全明确，因此，必须进行进一步研究以阐明肿瘤细胞内部的超微结构和代谢变化。开发适用于临床环境的次声发生器将是一个重要的行动方向。
