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泼尼松龙治疗皮肌炎导致单克隆 B 细胞淋巴细胞增多症加重。

Monoclonal B-cell Lymphocytosis Exacerbated by Prednisolone Therapy for Dermatomyositis.

机构信息

Department of Hematology, Asahi General Hospital, Japan.

Research Center for Allergy and Clinical Immunology, Asahi General Hospital, Japan.

出版信息

Intern Med. 2021 Sep 1;60(17):2853-2858. doi: 10.2169/internalmedicine.6956-20. Epub 2021 Mar 22.

Abstract

Lymphoproliferative diseases have been associated with various autoimmune diseases. We experienced a case of non-chronic lymphocytic leukemia type monoclonal B-cell lymphocytosis (MBL) that was exacerbated by increasing prednisolone for dermatomyositis and then improved by decreasing the dosage. Because MBL is difficult to diagnose, cases like ours may not be rare. These findings will facilitate our understanding of the mechanism underlying lymphoproliferative diseases and autoimmune diseases.

摘要

淋巴增生性疾病与各种自身免疫性疾病有关。我们遇到一例非慢性淋巴细胞白血病型单克隆 B 细胞淋巴增生症(MBL),因皮肌炎增加泼尼松龙而加重,随后减少剂量后改善。由于 MBL 难以诊断,像我们这样的病例可能并不少见。这些发现将有助于我们理解淋巴增生性疾病和自身免疫性疾病的发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3c/8479216/2293c9869c30/1349-7235-60-2853-g001.jpg

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