成人肝移植受者的长期管理
Long-term Management of the Adult Liver Transplantation Recipients.
作者信息
Choudhary Narendra S, Saraf Neeraj, Saigal Sanjiv, Soin Arvinder S
机构信息
Institute of Liver Transplantation and Regenerative Medicine, Medanta The Medicity, Gurgaon, Delhi (NCR), India.
出版信息
J Clin Exp Hepatol. 2021 Mar-Apr;11(2):239-253. doi: 10.1016/j.jceh.2020.06.010. Epub 2020 Jul 2.
Abstract
The survival of liver transplantation (LT) recipients has been improved remarkably in short-term. The major causes of mortality in long-term include nonimmunological causes such as cardiovascular, de novo malignancy, chronic kidney disease, and recurrence of primary disease. Rejection-related mortality is rare in the long-term after LT. We discuss nonrejection causes of long-term morbidity/mortality, risk factors, and management strategies in LT recipients. In addition, we discuss osteoporosis, contraception, and pregnancy in LT recipients.
摘要
肝移植（LT）受者的短期生存率有了显著提高。长期死亡的主要原因包括非免疫性原因，如心血管疾病、新发恶性肿瘤、慢性肾病以及原发性疾病的复发。肝移植术后长期与排斥反应相关的死亡很罕见。我们讨论肝移植受者长期发病/死亡的非排斥原因、危险因素及管理策略。此外，我们还讨论肝移植受者的骨质疏松、避孕和妊娠问题。
相似文献
1
Long-term Management of the Adult Liver Transplantation Recipients.成人肝移植受者的长期管理
J Clin Exp Hepatol. 2021 Mar-Apr;11(2):239-253. doi: 10.1016/j.jceh.2020.06.010. Epub 2020 Jul 2.
2
Impact of living donor liver transplantation on long-term cardiometabolic and graft outcomes in cirrhosis due to nonalcoholic steatohepatitis.非酒精性脂肪性肝炎相关肝硬化患者中行活体肝移植对长期心代谢及移植物结局的影响。
Clin Transplant. 2023 Sep;37(9):e15008. doi: 10.1111/ctr.15008. Epub 2023 May 4.
3
Recurrent primary sclerosing cholangitis in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study: Comparison of risk factors between living and deceased donor recipients.成人对成人活体肝移植队列研究中的复发性原发性硬化性胆管炎：活体供肝与尸体供肝受者的危险因素比较
Liver Transpl. 2016 Sep;22(9):1214-22. doi: 10.1002/lt.24496. Epub 2016 Aug 2.
4
Long-term Care of the Adult Liver Transplant Recipient.成人肝移植受者的长期护理
J Clin Exp Hepatol. 2022 Nov-Dec;12(6):1547-1556. doi: 10.1016/j.jceh.2022.03.012. Epub 2022 Apr 11.
5
Good Long-Term Outcomes in Patients With Primary Sclerosing Cholangitis Undergoing Living Donor Liver Transplantation.接受活体供肝移植的原发性硬化性胆管炎患者的良好长期预后。
J Clin Exp Hepatol. 2020 Sep-Oct;10(5):442-447. doi: 10.1016/j.jceh.2020.02.002. Epub 2020 Feb 14.
6
Sustained Virological Response Is Associated with a Decreased Risk of Posttransplant Diabetes Mellitus in Liver Transplant Recipients with Hepatitis C-Related Liver Disease.持续病毒学应答与丙型肝炎相关肝病肝移植受者移植后糖尿病发病风险降低相关。
Liver Transpl. 2018 Dec;24(12):1665-1672. doi: 10.1002/lt.25351.
7
NAFLD and liver transplantation: Disease burden, current management and future challenges.非酒精性脂肪性肝病与肝移植：疾病负担、当前管理及未来挑战
JHEP Rep. 2020 Oct 9;2(6):100192. doi: 10.1016/j.jhepr.2020.100192. eCollection 2020 Dec.
8
Potential benefit of mixed lymphocyte reaction assay-based immune monitoring after living donor liver transplantation for recipients with autoimmune hepatitis.基于混合淋巴细胞反应试验的免疫监测对自身免疫性肝炎受者活体肝移植后的潜在益处。
Transplant Proc. 2014 Apr;46(3):785-9. doi: 10.1016/j.transproceed.2013.11.123.
9
Recurrence of disease following organ transplantation in autoimmune liver disease and systemic lupus erythematosus.自身免疫性肝病和系统性红斑狼疮患者器官移植后疾病复发。
Cell Immunol. 2020 Jan;347:104021. doi: 10.1016/j.cellimm.2019.104021. Epub 2019 Nov 16.
10
Liver Transplantation: East versus West.肝移植：东方与西方
J Clin Exp Hepatol. 2013 Sep;3(3):243-53. doi: 10.1016/j.jceh.2013.08.004. Epub 2013 Sep 12.
引用本文的文献
1
The impact of donor liver fibrosis on the outcomes of patients who undergo liver transplant: a cohort study from UNOS database.供体肝纤维化对肝移植患者预后的影响：一项来自器官共享联合网络（UNOS）数据库的队列研究
Front Med (Lausanne). 2025 Apr 10;12:1547200. doi: 10.3389/fmed.2025.1547200. eCollection 2025.
2
Prevalence of Modifiable Risk Factors for de novo Malignancies After Living Donor Liver Transplantation.活体肝移植后新发恶性肿瘤可改变危险因素的患病率。
J Clin Exp Hepatol. 2024 May-Jun;14(3):101362. doi: 10.1016/j.jceh.2024.101362. Epub 2024 Feb 17.
3
Nutritional Management of a Liver Transplant Candidate.肝移植候选者的营养管理
J Clin Exp Hepatol. 2023 Sep-Oct;13(5):878-894. doi: 10.1016/j.jceh.2023.03.012. Epub 2023 Apr 6.
4
The Renal Histological Correlates of Refractory Renal Dysfunction After Liver Transplantation.肝移植后难治性肾功能障碍的肾脏组织学关联
J Clin Exp Hepatol. 2023 Jul-Aug;13(4):586-591. doi: 10.1016/j.jceh.2023.01.010. Epub 2023 Jan 30.
5
Bridging the Gap: Pregnancy-And Lactation-Associated Osteoporosis.弥合差距：妊娠和哺乳期相关骨质疏松症
Diagnostics (Basel). 2023 May 3;13(9):1615. doi: 10.3390/diagnostics13091615.
本文引用的文献
1
De Novo Malignancy After Living Donor Liver Transplantation: A Large Volume Experience.活体肝移植术后新发恶性肿瘤：大宗病例经验
J Clin Exp Hepatol. 2020 Sep-Oct;10(5):448-452. doi: 10.1016/j.jceh.2020.02.001. Epub 2020 Feb 13.
2
Good Long-Term Outcomes in Patients With Primary Sclerosing Cholangitis Undergoing Living Donor Liver Transplantation.接受活体供肝移植的原发性硬化性胆管炎患者的良好长期预后。
J Clin Exp Hepatol. 2020 Sep-Oct;10(5):442-447. doi: 10.1016/j.jceh.2020.02.002. Epub 2020 Feb 14.
3
Pregnancy After Liver Transplantation: Outcomes From a Single-Center Experience.肝移植后的妊娠：单中心经验的结果
J Clin Exp Hepatol. 2020 Jul-Aug;10(4):329-333. doi: 10.1016/j.jceh.2019.10.002. Epub 2019 Oct 30.
4
Posttransplant Complications Predict Alcohol Relapse in Liver Transplant Recipients.移植后并发症可预测肝移植受者的酒精复饮。
Liver Transpl. 2020 Mar;26(3):379-389. doi: 10.1002/lt.25712. Epub 2020 Jan 31.
5
Preventive Strategies for Nonalcoholic Fatty Liver Disease After Liver Transplantation.肝移植后非酒精性脂肪性肝病的预防策略
J Clin Exp Hepatol. 2019 Sep-Oct;9(5):619-624. doi: 10.1016/j.jceh.2019.05.004. Epub 2019 May 30.
6
Screening of Cardiovascular Disease in Nonalcoholic Fatty Liver Disease: Whom and How?非酒精性脂肪性肝病中心血管疾病的筛查：对象与方法？
J Clin Exp Hepatol. 2019 Jul-Aug;9(4):506-514. doi: 10.1016/j.jceh.2019.02.005. Epub 2019 Feb 15.
7
Bone Diseases in Patients with Chronic Liver Disease.慢性肝病患者的骨骼疾病。
Int J Mol Sci. 2019 Aug 31;20(17):4270. doi: 10.3390/ijms20174270.
8
Body Weight Parameters are Related to Morbidity and Mortality After Liver Transplantation: A Systematic Review and Meta-analysis.体重参数与肝移植后发病率和死亡率相关：系统评价和荟萃分析。
Transplantation. 2019 Nov;103(11):2287-2303. doi: 10.1097/TP.0000000000002811.
9
Pregnancy Outcomes After Liver Transplantation: A Systematic Review.肝移植后的妊娠结局：一项系统评价
Transplant Proc. 2019 Mar;51(2):446-449. doi: 10.1016/j.transproceed.2019.01.014. Epub 2019 Jan 4.
10
Liver transplantation and atrial fibrillation: A meta-analysis.肝移植与心房颤动：一项荟萃分析。
World J Hepatol. 2018 Oct 27;10(10):761-771. doi: 10.4254/wjh.v10.i10.761.
Zotero 插件