Xu Renfeng, Wang Zhengchao
Provincial Key Laboratory for Developmental Biology and Neurosciences, Provincial University Key Laboratory of Sport and Health Science, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.
Front Physiol. 2021 Mar 5;12:649295. doi: 10.3389/fphys.2021.649295. eCollection 2021.
FoxO1 is a member of the forkhead transcription factor family subgroup O (FoxO), which is expressed in many cell types, and participates in various pathophysiological processes, including cell proliferation, apoptosis, autophagy, metabolism, inflammatory response, cytokine expression, immune differentiation, and oxidative stress resistance. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in the women of childbearing age, which is regulated a variety of signaling pathways. Currently, the specific mechanism underlying the pathogenesis of PCOS is still unclear. As an important transcription factor, FoxO1 activity might be involved in the pathophysiology of PCOS. PCOS has been associated with insulin resistance and low-grade inflammatory response. Therefore, the studies regarding the role of FoxO1 in the incidence and associated complications of PCOS will help provide novel ideas for establishing the treatment strategy of PCOS.
叉头框蛋白O1（FoxO1）是叉头转录因子家族O亚组（FoxO）的成员之一，在多种细胞类型中表达，并参与各种病理生理过程，包括细胞增殖、凋亡、自噬、代谢、炎症反应、细胞因子表达、免疫分化和抗氧化应激。多囊卵巢综合征（PCOS）是育龄期女性最常见的内分泌紊乱疾病，受多种信号通路调控。目前，PCOS发病机制的具体原因仍不清楚。作为一种重要的转录因子，FoxO1的活性可能参与了PCOS的病理生理过程。PCOS与胰岛素抵抗和低度炎症反应有关。因此，关于FoxO1在PCOS发病及相关并发症中的作用的研究，将有助于为制定PCOS的治疗策略提供新思路。
