Shibata S, Tsutsumi K, Inoue M, Fukushima M, Mori K
Department of Neurosurgery, Nagasaki University School of Medicine, Japan.
Neurosurgery. 1988 Apr;22(4):669-75. doi: 10.1227/00006123-198804000-00008.
Ultramicromorphological changes of the cerebral vessels were studied by observation of ultrathin section specimens under the transmission electron microscope, vascular cast specimens under the scanning electron microscope, and freeze-fracture replica specimens under the transmission electron microscope. Extensive infarction was found in areas supplied by the middle cerebral artery, but the disturbances in the microvasculature of the lesion are not simple. Bleeding came from arterioles in the basal ganglia, a perforating arterial terminal zone, and from venules in the corticomedullary border, a cortical arterial terminal zone. The number of pinocytotic vesicles was 3 times normal in the capillaries of ischemic cortex, and vesicle size increased 1.3 times. The tight junctions revealed discontinuity of strand-composing intramembranous particles, but no obvious disruption. It is concluded, therefore, that vesicular transport plays a major role in the increase of capillary permeability during experimental infarction.
通过透射电子显微镜观察超薄切片标本、扫描电子显微镜观察血管铸型标本以及透射电子显微镜观察冷冻断裂复制品标本，研究了脑血管的超微形态变化。在大脑中动脉供血区域发现广泛梗死，但病变部位微血管的紊乱并非单一情况。出血来自基底节区的小动脉（穿通动脉终末区）以及皮质髓质交界区的小静脉（皮质动脉终末区）。缺血皮质毛细血管内吞小泡数量为正常的3倍，小泡大小增加1.3倍。紧密连接显示构成股线的膜内颗粒连续性中断，但无明显破坏。因此得出结论，在实验性梗死期间，小泡运输在毛细血管通透性增加中起主要作用。
