神经肽Y在下丘脑室旁核中的心血管作用：清醒状态下的Long Evans大鼠和Brattleboro大鼠实验

Cardiovascular actions of neuropeptide Y in the hypothalamic paraventricular nucleus of conscious Long Evans and Brattleboro rats.

作者信息

Harland D, Bennett T, Gardiner S M

机构信息

Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, U.K.

出版信息

Neurosci Lett. 1988 Feb 29;85(2):239-43. doi: 10.1016/0304-3940(88)90358-8.

DOI:10.1016/0304-3940(88)90358-8

PMID:3374840

Abstract

The central cardiovascular effects of neuropeptide Y (NPY) have been investigated by microinjection of the peptide into the hypothalamic paraventricular nucleus (PVN) of conscious rats. NPY (100 ng) elicited a significant bradycardia in both Long Evans (control) rats (-27 +/- beats/min) and vasopressin-deficient Brattleboro rats (-19 +/- 6 beats/min). There was a slight fall in systolic blood pressure in both strains which was significant only in Long Evans rats. A higher dose of NPY (1000 ng) had no significant effect on blood pressure or heart rate, but produced a marked behavioural response characterized by initiation of foraging behaviour. These results provide further support for a role for NPY in central cardiovascular regulation, but provide no evidence of an indispensable involvement of vasopressin-containing pathways in the observed responses.

摘要

通过将神经肽Y（NPY）微量注射到清醒大鼠的下丘脑室旁核（PVN），对其心血管中枢效应进行了研究。NPY（100纳克）在长Evans（对照）大鼠（-27±次/分钟）和抗利尿激素缺乏的布拉特洛维大鼠（-19±6次/分钟）中均引起显著的心动过缓。两种品系的收缩压均略有下降，仅在长Evans大鼠中显著。更高剂量的NPY（1000纳克）对血压或心率无显著影响，但产生了以觅食行为开始为特征的明显行为反应。这些结果为NPY在心血管中枢调节中的作用提供了进一步支持，但没有证据表明含抗利尿激素的通路在观察到的反应中不可或缺。