Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Graduate University of Sciences and Technology, VAST, Hanoi, Vietnam.
Nat Prod Res. 2022 Aug;36(15):3931-3937. doi: 10.1080/14786419.2021.1900844. Epub 2021 Mar 22.
Three undescribed dihydrostilbene glycosides, 3,5-dihydroxyldihydrostilbene 4'--[6''--(4'''-hydroxylbenzoyl)]--D-glucopyranoside (), 3,5-dihydroxyldihydrostilbene 4'--(6''--galloyl)--D-glucopyranoside (), and 3,5-dihydroxyldihydrostilbene 4'--[6''--(3''',4'''-dimethoxyl)galloyl]--D-glucopyranoside (), and seven known compounds, kaempferol 3---D-glucopyranoside (), isoquercitrin (), kaempferol 3--L-rhamnoside (), quercitrin (, (6,9)-roseoside (), (-)-epicatechin 3--gallate (), and (-)-epigallocatechin 3--gallate () have been isolated from the methanol extract of the leaves of var. (J.W.Mast.) Kitam. (synnonym of (Mast.) H.T.Chang) (Theaceae). Their structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. All compounds were evaluated for cytotoxic activity against human oral cancer (CAL27) and human breast cancer (MDAMB231) cell lines. Compound showed significant cytotoxic activity against CAL27 and MDAMB231 cell lines with IC values of 9.78 ± 0.25 and 3.27 ± 0.18 μM, respectively, compared to those of positive control, capecitabine (IC values of 8.20 ± 0.75 and 5.20 ± 0.89 μM).
从 var. (J.W.Mast.) Kitam. (synonym of (Mast.) H.T.Chang) (Theaceae) 的叶甲醇提取物中分离得到了三种未描述的二氢二苯乙烯糖苷，3,5-二羟基二氢二苯乙烯 4'--[6''--(4'''-羟基苯甲酰)]--D-吡喃葡萄糖苷 ()、3,5-二羟基二氢二苯乙烯 4'--(6''--没食子酰基)--D-吡喃葡萄糖苷 () 和 3,5-二羟基二氢二苯乙烯 4'--[6''--(3'',4' '-二甲氧基)没食子酰基]--D-吡喃葡萄糖苷 ()，以及七种已知化合物，山柰酚 3---D-吡喃葡萄糖苷 ()、异槲皮苷 ()、山柰酚 3--L-鼠李糖苷 ()、槲皮苷 (、(6,9)-玫瑰苷 ()、(-)-表儿茶素 3--没食子酸酯 () 和 (-)-表没食子儿茶素 3--没食子酸酯 ()。它们的结构通过光谱方法（1D-、2D-NMR）和质谱确定。所有化合物均针对人口腔癌细胞（CAL27）和人乳腺癌细胞（MDAMB231）进行了细胞毒性评估。化合物 对 CAL27 和 MDAMB231 细胞系表现出显著的细胞毒性活性，IC 值分别为 9.78 ± 0.25 和 3.27 ± 0.18 μM，与阳性对照卡培他滨（IC 值分别为 8.20 ± 0.75 和 5.20 ± 0.89 μM）相比。
