Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
Curr Protein Pept Sci. 2021 Oct 26;22(4):336-360. doi: 10.2174/1389203722666210322145810.
Microbial resistance to conventional therapeutics has become a significant threat to human society. Biofilms serve as the major virulence factor for the microorganisms by resisting the antibiotics and host innate immune system. Antimicrobial peptides (AMPs) have emerged as a potential alternative to conventional therapeutics due to their exceptional anti-biofilm and broad-spectrum antimicrobial property. Researchers have applied bioinformatics, genetic engineering, tissue culture, and drug delivery approaches to enhance the production and therapeutic efficacy of antimicrobial peptides. This review comprehensively describes the various aspects of AMPs with particular focus on their anti-biofilm potential. Other detailed information highlighted in this review includes different classes of AMPs, their mode of action, and anti-biofilm activity both alone and in synergy with other AMPs or conventional antibiotics. Further, challenges and opportunities of AMPs based drug delivery systems such as nano-formulations, polymeric micelles, and vesicles are also summarized.
微生物对传统疗法的耐药性已成为人类社会的重大威胁。生物膜通过抵抗抗生素和宿主固有免疫系统成为微生物的主要毒力因子。由于其出色的抗生物膜和广谱抗菌特性，抗菌肽 (AMP) 已成为传统疗法的潜在替代品。研究人员已经应用生物信息学、基因工程、组织培养和药物输送方法来提高抗菌肽的产量和治疗效果。本综述全面描述了 AMP 的各个方面，特别关注其抗生物膜的潜力。本综述还强调了其他详细信息，包括不同类别的 AMP、它们的作用模式以及单独使用和与其他 AMP 或传统抗生素联合使用时的抗生物膜活性。此外，还总结了基于 AMP 的药物输送系统（如纳米制剂、聚合物胶束和囊泡）的挑战和机遇。
