Clin Neuropathol. 2021 May-Jun;40(3):134-141. doi: 10.5414/NP301335.
The co-existence of two independent brain tumors at the same anatomical site is rare and occurs as a "collision tumor" or "tumor-to-tumor metastasis." In intracranial location, meningioma is the most common neoplasm in such coincidences.
We present a case involving a 31-year-old woman with a complex tumor consisting of chordoma and meningioma in the petroclival region. The patient presented with left facial numbness, ataxia, and left-sided hemiparesis. Computed tomography and magnetic resonance imaging showed a well-demarcated, intradural, extra-axial tumor mass in the petroclival region. After complete total resection, histopathological examination revealed two different parts of the tumor, consisting of chordoma and meningioma. Therefore, additional radiation therapy and adjuvant chemotherapy were given.
To the best of our knowledge, this is the first description of the simultaneous occurrence of chordoma and meningioma in the same anatomical location. In such a scenario, differential diagnosis of choroid meningioma and chordoma is required. The correct recognition of both components is important for treating this complex tumor, and its separate elements may require independent approaches.
同一解剖部位同时存在两个独立的脑肿瘤较为罕见，通常表现为“碰撞瘤”或“肿瘤对肿瘤转移”。在颅内位置，脑膜瘤是此类偶发肿瘤中最常见的肿瘤。
我们报告了一例 31 岁女性患者，其在岩斜区存在由脊索瘤和脑膜瘤组成的复杂肿瘤。该患者表现为左侧面部麻木、共济失调和左侧偏瘫。计算机断层扫描和磁共振成像显示在岩斜区有一个边界清楚的、硬脑膜内、硬脑膜外的肿瘤肿块。在完全切除后，组织病理学检查显示肿瘤有两个不同的部分，由脊索瘤和脑膜瘤组成。因此，给予了额外的放射治疗和辅助化疗。
据我们所知，这是首例在同一解剖部位同时发生脊索瘤和脑膜瘤的描述。在这种情况下，需要对脉络丛脑膜瘤和脊索瘤进行鉴别诊断。正确识别这两个成分对于治疗这种复杂的肿瘤很重要，其不同的成分可能需要独立的治疗方法。
