Alexander J
University of Strathclyde, Immunology Division, Todd Centre, Glasgow.
Parasitology. 1988 Apr;96 ( Pt 2):297-302. doi: 10.1017/s0031182000058303.
Female DBA/2 mice were found to be highly resistant to Leishmania mexicana and rarely developed lesions even when inoculated subcutaneously with high numbers (5 x 10(6] of amastigotes. Male DBA/2 mice, on the other hand, were much more susceptible to this parasite and often developed non-healing lesions even when inoculated subcutaneously with comparatively few (5 X 10(4] amastigotes. Conversely, although both male and female DBA/2 mice developed ulcerating lesions when inoculated subcutaneously with L. major amastigotes, lesions invariably healed in males but did not heal in females. Male DBA/2 mice recovered from L. major infection subsequently were found to be resistant to subcutaneous challenge with L. mexicana. Conversely female DBA/2 mice that had failed to develop lesions when infected with L. mexicana developed lesions which healed following subcutaneous challenge with L. major. Thus there is bilateral cross-immunity between L. mexicana and L. major in DBA/2 mice which overrides differences in sex-determined susceptibility to both organisms.
已发现雌性DBA/2小鼠对墨西哥利什曼原虫具有高度抗性，即使皮下接种大量（5×10⁶）无鞭毛体也很少出现病变。另一方面，雄性DBA/2小鼠对这种寄生虫更易感，即使皮下接种相对较少（5×10⁴）无鞭毛体也常出现不愈合的病变。相反，尽管雄性和雌性DBA/2小鼠皮下接种硕大利什曼原虫无鞭毛体时都会出现溃疡性病变，但雄性的病变总是会愈合，而雌性的则不会愈合。随后发现，从硕大利什曼原虫感染中恢复的雄性DBA/2小鼠对皮下接种墨西哥利什曼原虫具有抗性。相反，感染墨西哥利什曼原虫时未出现病变的雌性DBA/2小鼠，在皮下接种硕大利什曼原虫后出现了愈合的病变。因此，在DBA/2小鼠中，墨西哥利什曼原虫和硕大利什曼原虫之间存在双向交叉免疫，这种免疫超越了性别决定的对这两种生物体易感性的差异。
