Eldeeb Fatma, Wahid Reham M, Alakad Rania
Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Member of Interactive Dermatology Research Foundation, Cairo, Egypt.
J Cosmet Dermatol. 2022 Jan;21(1):247-253. doi: 10.1111/jocd.14088. Epub 2021 Mar 28.
Treatment of acanthosis nigricans (AN) is challenging, and new modalities are being explored continuously to increase the therapeutic efficacy.
To evaluate the efficacy and safety of fractional CO2 laser compared to trichloroacetic acid (TCA) peel in the treatment of pseudo-acanthosis nigricans (pseudo-AN).
The study included 40 patients with pseudo-AN on the neck and axilla allocated into two groups each containing 20 patients. Group (A) was treated with TCA 20% peel applied on the pigmented area while group (B) received fractional CO2 laser. Both treatments were performed till complete clearance or for a maximum of four treatment sessions. Patients with excellent response were further followed up for 6 months after the end of treatment.
Both modalities were effective in the treatment of pseudo-AN; however, the therapeutic response was significantly higher in the fractional CO2 laser group compared to the TCA peel group (p < 0.01). Marked to excellent response (51%-100% clearance of AN lesions) was achieved in 85% of the patients in the fractional laser group versus 10% of the patients in the TCA group. Adverse effects, for example, persistent erythema, post-inflammatory hyperpigmentation, and burning sensation, were also statistically higher in the TCA group compared to the laser group (p = 0.04).
Fractional CO2 laser is a promising effective and well-tolerated treatment modality for pseudo-acanthosis nigricans.
黑棘皮病（AN）的治疗具有挑战性，人们不断探索新的治疗方法以提高治疗效果。
评估与三氯乙酸（TCA）剥脱术相比，二氧化碳点阵激光治疗假性黑棘皮病（pseudo-AN）的疗效和安全性。
该研究纳入40例颈部和腋窝患有假性黑棘皮病的患者，分为两组，每组20例。A组在色素沉着区域涂抹20%的TCA进行治疗，而B组接受二氧化碳点阵激光治疗。两种治疗均持续进行直至完全清除或最多进行4次治疗。对反应良好的患者在治疗结束后进一步随访6个月。
两种治疗方法对假性黑棘皮病均有效；然而，与TCA剥脱术组相比，二氧化碳点阵激光组的治疗反应明显更高（p < 0.01）。点阵激光组85%的患者达到显著至良好的反应（黑棘皮病皮损清除率为51%-100%），而TCA组为10%。与激光组相比，TCA组的不良反应，如持续性红斑、炎症后色素沉着和烧灼感，在统计学上也更高（p = 0.04）。
二氧化碳点阵激光是一种有前景的治疗假性黑棘皮病的有效且耐受性良好的治疗方法。
