Department of Clinical Nutrition, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
J Hum Nutr Diet. 2021 Oct;34(5):792-806. doi: 10.1111/jhn.12883. Epub 2021 Apr 9.
To explore the vitamin D status with its demographic and lifestyle factors including dietary, supplementation, and physical activity in 0-5 years old children.
This was a large population-based cross-sectional multicentre study in which the children were recruited from 12 Children's Health Care Centers by a stratified cluster random-sampling method in 10 cities in Jiangsu Province, China.
A total number of 5289 children were investigated. The prevalence of vitamin D deficiency was 30.1%. The concentration of 25 hydroxyvitamin D was 64.0 (46.3-83.0) nmol mL after adjustment for covariates. Children with higher risk of vitamin D deficiency were more likely to be at older age, girls, survey conducted in spring, location in southern Jiangsu province, residence in urban, outdoor activity < 2 h day (all p < 0.05). Moreover, those with lower risk were more likely to be the number of parity ≥ 2 times, vitamin D supplementation from birth to 6 months, the initial time of vitamin D supplementation after birth ≤ 1 months, vitamin D and calcium supplementation in the last 3 months, and dose of vitamin D supplementation > 400 IU day (all p < 0.05). Children with preferences for sweets, meat consumption > 150.0 g day , milk consumption < 250 mL day , time of sleeping < 10 h day had higher risks of vitamin D deficiency. However, these relationships were affected by demographics.
Vitamin D status during the first five years of life was suboptimal and was associated with demographic and lifestyle determinants including milk, meat, sweets, vitamin D and calcium supplementation, sleeping and outdoor activity.
本研究旨在探讨 0-5 岁儿童的维生素 D 状况及其与人口统计学和生活方式因素的关系，包括饮食、补充剂和体力活动。
这是一项基于人群的大型横断面多中心研究，通过分层整群随机抽样方法，在江苏省的 10 个城市的 12 个儿童保健中心招募了这些儿童。
共调查了 5289 名儿童。维生素 D 缺乏的患病率为 30.1%。调整协变量后，25-羟维生素 D 浓度为 64.0（46.3-83.0）nmol/ml。维生素 D 缺乏风险较高的儿童更有可能年龄较大、女孩、春季调查、位于江苏南部、居住在城市、户外活动<2 小时/天（均 P<0.05）。此外，具有较低风险的儿童更有可能是多胎≥2 次、出生至 6 个月时补充维生素 D、出生后维生素 D 补充的初始时间≤1 个月、过去 3 个月内补充维生素 D 和钙、维生素 D 补充剂量>400IU/天（均 P<0.05）。喜欢甜食、肉类摄入量>150.0g/天、牛奶摄入量<250ml/天、睡眠时间<10 小时/天的儿童维生素 D 缺乏的风险较高。然而，这些关系受到人口统计学因素的影响。
0-5 岁儿童生命早期的维生素 D 状况不理想，与包括牛奶、肉类、甜食、维生素 D 和钙补充剂、睡眠和户外活动在内的人口统计学和生活方式因素有关。
