Zhang Jiajia, Chen Lixin, Ye Jinghua
Department of Obstetrics and Gynecology,Hangzhou Women's Hospital, Hangzhou, China.
Department of Obstetrics and Gynecology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Wenzhou, China.
Ann Palliat Med. 2021 Mar;10(3):3404-3409. doi: 10.21037/apm-21-458. Epub 2021 Mar 18.
This study aimed to investigate the relationship between myonectin levels and metabolic and hormonal disorders in patients with polycystic ovary syndrome (PCOS).
One hundred PCOS patients who sought medical advice from September 2017 to March 2019 in our hospital were selected as the PCOS group, while 100 healthy women matched for age and body mass index (BMI) with the PCOS patients were selected as the control group. General clinical information, myonectin levels, and metabolism and sex hormone-related indicators of the two groups were compared, and the correlation between myonectin, metabolism, and sex hormones was analyzed.
There were no significant differences in age, BMI, blood pressure, or other general clinical information between the two groups (P>0.05). Compared with the control group, the levels of myonectin, sex hormone-binding globulin (SHBG), and high-density lipoprotein cholesterol (HDL-C) in the PCOS group were significantly decreased (P<0.05), while the levels of fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), luteinizing hormone (LH), and testosterone were significantly increased (P<0.05). Pearson correlation analysis showed that the level of myonectin was negatively correlated with BMI, FBG, HOMA-IR, TG, and testosterone but was positively correlated with SHBG and HDL-C. Multivariate linear regression analysis showed that the level of myonectin was negatively correlated with BMI, HOMA-IR, and TG but positively correlated with SHBG and HDL-C.
There is a correlation between the level of myonectin and multiple metabolic and hormone indices in PCOS patients indicating that myonectin may be an effective index to predict metabolic and hormone disorders in PCOS patients.
本研究旨在探讨多囊卵巢综合征（PCOS）患者中肌连接蛋白水平与代谢及激素紊乱之间的关系。
选取2017年9月至2019年3月在我院就诊的100例PCOS患者作为PCOS组，同时选取100例年龄和体重指数（BMI）与PCOS患者相匹配的健康女性作为对照组。比较两组的一般临床信息、肌连接蛋白水平以及代谢和性激素相关指标，并分析肌连接蛋白、代谢和性激素之间的相关性。
两组在年龄、BMI、血压或其他一般临床信息方面无显著差异（P>0.05）。与对照组相比，PCOS组的肌连接蛋白、性激素结合球蛋白（SHBG）和高密度脂蛋白胆固醇（HDL-C）水平显著降低（P<0.05），而空腹血糖（FBG）、胰岛素抵抗稳态模型评估（HOMA-IR）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、促黄体生成素（LH）和睾酮水平显著升高（P<0.05）。Pearson相关性分析显示，肌连接蛋白水平与BMI、FBG、HOMA-IR、TG和睾酮呈负相关，但与SHBG和HDL-C呈正相关。多变量线性回归分析显示，肌连接蛋白水平与BMI、HOMA-IR和TG呈负相关，但与SHBG和HDL-C呈正相关。
PCOS患者的肌连接蛋白水平与多种代谢和激素指标之间存在相关性，表明肌连接蛋白可能是预测PCOS患者代谢和激素紊乱的有效指标。
