新的Ther1衍生的SINE Squam3在有鳞类爬行动物中。
New Ther1-derived SINE Squam3 in scaled reptiles.
作者信息
Vassetzky Nikita S, Kosushkin Sergei A, Korchagin Vitaly I, Ryskov Alexey P
机构信息
Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
出版信息
Mob DNA. 2021 Mar 22;12(1):10. doi: 10.1186/s13100-021-00238-y.
BACKGROUND
SINEs comprise a significant part of animal genomes and are used to study the evolution of diverse taxa. Despite significant advances in SINE studies in vertebrates and higher eukaryotes in general, their own evolution is poorly understood.
RESULTS
We have discovered and described in detail a new Squam3 SINE specific for scaled reptiles (Squamata). The subfamilies of this SINE demonstrate different distribution in the genomes of squamates, which together with the data on similar SINEs in the tuatara allowed us to propose a scenario of their evolution in the context of reptilian evolution.
CONCLUSIONS
Ancestral SINEs preserved in small numbers in most genomes can give rise to taxa-specific SINE families. Analysis of this aspect of SINEs can shed light on the history and mechanisms of SINE variation in reptilian genomes.
背景
短散在重复序列（SINEs）构成动物基因组的重要部分，被用于研究不同分类群的进化。尽管总体上脊椎动物和高等真核生物的SINE研究取得了显著进展，但对其自身进化的了解却很少。
结果
我们发现并详细描述了一种新的、特定于有鳞爬行动物（有鳞目）的Squam3 SINE。这种SINE的亚家族在有鳞目动物的基因组中表现出不同的分布，结合楔齿蜥中类似SINE的相关数据，使我们能够提出其在爬行动物进化背景下的进化情景。
结论
大多数基因组中少量保留的祖先SINEs可产生特定分类群的SINE家族。对SINEs这一方面的分析能够揭示爬行动物基因组中SINE变异的历史和机制。
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