罕见变异增加了患严重 COVID-19 的风险。
Rare variants increase the risk of severe COVID-19.
机构信息
Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Nijmegen, Netherlands.
Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
出版信息
Elife. 2021 Mar 23;10:e67860. doi: 10.7554/eLife.67860.
Abstract
Evidence is mounting that rare loss-of-function variants in the gene predispose men with no medical history to severe forms of COVID-19.
摘要
越来越多的证据表明，基因中罕见的功能丧失变异使没有病史的男性易患严重形式的 COVID-19。
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本文引用的文献
1
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study.TLR7 变异与男性 COVID-19 重症患者的相关性：巢式病例对照研究的结果。
Elife. 2021 Mar 2;10:e67569. doi: 10.7554/eLife.67569.
2
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.COVID-19 危重症患者的 I 型 IFN 免疫先天缺陷。
Science. 2020 Oct 23;370(6515). doi: 10.1126/science.abd4570. Epub 2020 Sep 24.
3
Presence of Genetic Variants Among Young Men With Severe COVID-19.年轻男性严重 COVID-19 患者中存在遗传变异。
JAMA. 2020 Aug 18;324(7):663-673. doi: 10.1001/jama.2020.13719.
4
Long-term interferon-gamma therapy for patients with chronic granulomatous disease.慢性肉芽肿病患者的长期干扰素-γ治疗
Clin Infect Dis. 2004 Sep 1;39(5):692-9. doi: 10.1086/422993. Epub 2004 Aug 16.
5
A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease.一项关于γ干扰素预防慢性肉芽肿病感染的对照试验。
N Engl J Med. 1991 Feb 21;324(8):509-16. doi: 10.1056/NEJM199102213240801.
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