Groupe hospitalier Paris Saint-Joseph, 75014 Paris, France.
Groupe hospitalier Paris Saint-Joseph, 75014 Paris, France; Inserm UMR 1153 Center of Research in Epidemiology and Statistics, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
J Med Vasc. 2021 Apr;46(2):53-65. doi: 10.1016/j.jdmv.2020.12.005. Epub 2021 Feb 5.
Lung cancer and atherosclerosis share common risk factors. Literature data suggest that the prevalence of lung malignancy in patients with peripheral arterial disease (PAD) is higher than in the general population. Our goal was to determine, through a systematic literature review, the prevalence of lung cancer in patients with PAD.
We consulted available publications in the Cochrane library, MEDLINE, PUBMED, EMBASE, and ClinicalTrials.gov. We included all articles, written in English or French, published between 1990 and 2020 reporting the prevalence of lung cancer in patients with PAD (atherosclerotic aortic aneurysm or peripheral occlusive diseases). Patients with coronary artery disease, cardiac valvulopathy or carotid stenosis were not included. We did not include case reports. We performed a critical analysis of each article. Data were collected from two independent readers. A fixed effect model meta-analysis allowed to estimate a summary prevalence rate.
We identified 303 articles, and selected 19 articles according to selection criteria. A total of 16849 patients were included (mean age 68.3 years, 75.1% of males). Aortic aneurysms were found in 29% of patients and atherosclerotic occlusive disease in 66% of patients. Lung cancer was identified in 538 patients, representing a prevalence of 3%.
Lung cancer is found in 3% of patients with atherosclerotic PAD. This prevalence is higher than that found in lung cancer screening programs performed in the general population of smokers and former smokers. These patients should be screened for lung cancer. Their selection may dramatically increase the benefit of lung cancer screening.
肺癌和动脉粥样硬化有共同的危险因素。文献资料表明，周围动脉疾病（PAD）患者中肺癌的患病率高于普通人群。我们的目标是通过系统的文献回顾，确定 PAD 患者中肺癌的患病率。
我们查阅了 Cochrane 图书馆、MEDLINE、PUBMED、EMBASE 和 ClinicalTrials.gov 中可用的出版物。我们纳入了所有发表于 1990 年至 2020 年期间的英文或法文文章，报道了 PAD（动脉粥样硬化性主动脉瘤或外周闭塞性疾病）患者中肺癌的患病率。不包括冠心病、心脏瓣膜病或颈动脉狭窄患者。我们不包括病例报告。我们对每篇文章进行了批判性分析。数据由两名独立读者收集。固定效应模型荟萃分析可用于估计综合患病率。
我们共识别出 303 篇文章，根据选择标准选择了 19 篇文章。共纳入 16849 例患者（平均年龄 68.3 岁，75.1%为男性）。29%的患者有主动脉瘤，66%的患者有动脉粥样硬化闭塞性疾病。538 例患者被诊断为肺癌，患病率为 3%。
在动脉粥样硬化性 PAD 患者中，3%的患者患有肺癌。这一患病率高于在普通吸烟和曾吸烟人群中进行的肺癌筛查计划中发现的患病率。这些患者应进行肺癌筛查。他们的选择可能会极大地提高肺癌筛查的效益。
