速尿对清醒大鼠尿激肽释放酶排泄的影响：肾上腺切除术和去氧皮质酮治疗的影响。

Effect of frusemide on urinary kallikrein excretion in the conscious rat: influence of adrenalectomy and DOCA treatment.

作者信息

Obika L F, Amurawaiye B S, Etok-Akpan E, Oduleye S O

机构信息

Department of Physiology and Biochemistry, University of Ilorin, Nigeria.

出版信息

Pharmacol Res Commun. 1988 Jan;20(1):49-59. doi: 10.1016/s0031-6989(88)80606-4.

DOI:10.1016/s0031-6989(88)80606-4

PMID:3375289

Abstract

The effect of subcutaneous frusemide administration on urinary kallikrein excretion was studied in the conscious state, in control, adrenalectomized and DOCA-treated adrenalectomized rats. Frusemide increased urinary kallikrein excretion in the three groups of rats. Urine volume and urinary sodium and potassium excretions were also increased. These responses were however suppressed by adrenalectomy but normalized by DOCA treatment. It is concluded that frusemide's stimulation of urinary kallikrein excretion in the conscious rat is modulated by mineralocorticoid activity.

摘要

在清醒状态下，对正常、肾上腺切除以及用去氧皮质酮（DOCA）处理过的肾上腺切除大鼠，研究了皮下注射速尿对尿激肽释放酶排泄的影响。速尿可增加三组大鼠的尿激肽释放酶排泄量。尿量以及尿钠和钾的排泄量也增加。然而，这些反应在肾上腺切除后受到抑制，但经DOCA处理后恢复正常。结论是，速尿对清醒大鼠尿激肽释放酶排泄的刺激作用受盐皮质激素活性的调节。