来自牛因子VIII的多肽组分不影响人血小板聚集和血液凝固。

Polypeptide fraction from bovine factor VIII does not influence human platelet aggregation and blood coagulation.

作者信息

Baldacci M, Catalani R, Fascetti E, Gervasi G B

机构信息

Laboratori Baldacci S.p.A. Pisa, Italy.

出版信息

Pharmacol Res Commun. 1988 Jan;20(1):7-12. doi: 10.1016/s0031-6989(88)80602-7.

DOI:10.1016/s0031-6989(88)80602-7

PMID:3375291

Abstract

It is well known that high molecular weight bovine factor VIII is able to aggregate human platelets and possesses procoagulant activities. There is also growing body of evidence that the hydrolysis of bovine factor VIII abolishes its aggregating and coagulative properties. We have shown in this paper that a polypeptide fraction (molecular weight 1000-25000 daltons) from bovine factor VIII does not aggregate platelets nor affect blood coagulation. In this study we investigate the action of the polypeptide fraction derived from bovine factor VIII and suggest that its effect may occur only at endothelium level without an involvement of platelets as well as blood coagulation.

摘要

众所周知，高分子量牛因子VIII能够聚集人血小板并具有促凝血活性。也有越来越多的证据表明，牛因子VIII的水解会消除其聚集和凝血特性。我们在本文中表明，来自牛因子VIII的一个多肽组分（分子量1000 - 25000道尔顿）既不会聚集血小板，也不会影响血液凝固。在本研究中，我们研究了源自牛因子VIII的多肽组分的作用，并表明其作用可能仅在内皮水平发生，而不涉及血小板和血液凝固。