[人体内二肼苯哒嗪代谢物的定量鉴定]
[The quantitative identification of metabolites of dihydralazine in the human].
作者信息
Schneider T, Siegmund W, Zschiesche M, Kallwellis R, Scherber A
机构信息
Institut für Klinische Pharmakologie, Ernst-Moritz-Arndt-Universität Greifswald.
出版信息
Pharmazie. 1988 Jan;43(1):33-6.
PMID:3375299
Abstract
The metabolism of dihydralazine sulfate was studied in 11 hypertonic patients treated with that drug chronically. The metabolites were identified in urine with gc, dc, and hplc by comparison with synthesized reference compounds. Following metabolites could be verified: acetylated products, oxidation products, hydrazones and products of decomposition. Products resulting from reaction with nitrites could be not detected.
摘要
对11例长期使用硫酸双肼屈嗪治疗的高血压患者的药物代谢情况进行了研究。通过与合成的参考化合物比较，利用气相色谱（GC）、薄层色谱（DC）和高效液相色谱（HPLC）对尿液中的代谢产物进行了鉴定。可确认以下代谢产物：乙酰化产物、氧化产物、腙和分解产物。未检测到与亚硝酸盐反应产生的产物。
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