COVID-19 患者中与 IL-6 触发相关的短暂浆细胞异常
Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering.
机构信息
Department of Experimental Medicine, University of Rome "La Sapienza", 00161, Roma, Lazio, Italy.
Department of Emergency Medicine, University of Rome "La Sapienza", 00161, Roma, Lazio, Italy.
出版信息
Microbes Infect. 2021 May-Jun;23(4-5):104808. doi: 10.1016/j.micinf.2021.104808. Epub 2021 Mar 20.
An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.
一项针对 COVID-19 患者的异常单克隆丙种球蛋白血症的报道，但这种异常是否与疾病有关尚未阐明。为此，我们选择了一组 35 例 COVID-19 患者的拭子阳性，并检测了 IL-6 的血清水平、对主要病毒抗原的免疫反应和电泳图谱。IL-6 水平升高伴随着对病毒 Spike 蛋白的显著体液反应，揭示了γ区电泳图谱的改变。我们可以得出结论，IL-6 水平升高会触发体液反应，导致重症 COVID-19 患者出现短暂的浆细胞发育异常。
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