Department of Experimental Medicine, University of Rome "La Sapienza", 00161, Roma, Lazio, Italy.
Department of Emergency Medicine, University of Rome "La Sapienza", 00161, Roma, Lazio, Italy.
Microbes Infect. 2021 May-Jun;23(4-5):104808. doi: 10.1016/j.micinf.2021.104808. Epub 2021 Mar 20.
An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.
一项针对 COVID-19 患者的异常单克隆丙种球蛋白血症的报道，但这种异常是否与疾病有关尚未阐明。为此，我们选择了一组 35 例 COVID-19 患者的拭子阳性，并检测了 IL-6 的血清水平、对主要病毒抗原的免疫反应和电泳图谱。IL-6 水平升高伴随着对病毒 Spike 蛋白的显著体液反应，揭示了γ区电泳图谱的改变。我们可以得出结论，IL-6 水平升高会触发体液反应，导致重症 COVID-19 患者出现短暂的浆细胞发育异常。
