利培酮或氨磺必利治疗的精神分裂症患者中出现大分子泌乳素血症。
Occurrence of macroprolactinemia in schizophrenia patients treated with risperidone or amisulpride.
机构信息
Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, Zhejiang, China.
The Center for Disease Control and Prevention of Huzhou City, Zhejiang, China.
出版信息
Asia Pac Psychiatry. 2022 Mar;14(1):e12469. doi: 10.1111/appy.12469. Epub 2021 Mar 22.
OBJECTIVE
To investigate macroprolactinemia caused by antipsychotics and its clinical significance.
METHODS
A total of 133 patients with schizophrenia were selected, all of whom were treated with either risperidone or amisulpride alone. The levels of total prolactin (T-PRL) and macroprolactin (MPRL) were measured before treatment as well as the second, fourth, and sixth weeks of treatment.
RESULTS
After 2 weeks of treatment, 75.09% (100/133) of the patients met the diagnostic criteria for hyperprolactinemia, the incidence of macroprolactinemia was 43% (43/100), and MPRL levels were positively correlated T-PRL levels.
CONCLUSION
Risperidone and amisulpride caused hyperprolactinemia and macroprolactinemia; thus, detection of MPRL in the clinical setting should be performed as this phenomenon appears early in treatment (the second week) and continues, that can avoid unnecessary examination and treatment for asymptomatic patients with macroprolactinemia.
目的
研究抗精神病药引起的巨泌乳素血症及其临床意义。
方法
选取 133 例精神分裂症患者，均单独使用利培酮或氨磺必利治疗。分别在治疗前及治疗第 2、4、6 周时检测总泌乳素（T-PRL）和巨泌乳素（MPRL）水平。
结果
治疗 2 周后，133 例患者中有 75.09%（100/133）符合高泌乳素血症的诊断标准，巨泌乳素血症的发生率为 43%（43/100），MPRL 水平与 T-PRL 水平呈正相关。
结论
利培酮和氨磺必利均可引起高泌乳素血症和巨泌乳素血症；因此，在临床中应检测 MPRL，因为这种现象在治疗早期（第 2 周）就出现，并持续存在，这可以避免对无症状的巨泌乳素血症患者进行不必要的检查和治疗。
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