Department of Urology, Istanbul University Istanbul School of Medicine, Istanbul.
Department of Urology, University of Health Sciences, Ankara City Hospital, Ankara.
Arch Ital Urol Androl. 2021 Mar 18;93(1):31-34. doi: 10.4081/aiua.2021.1.31.
To investigate incidental prostate cancer (IPCa) rate and to determine prostate specific antigen (PSA) cut-off value indicating PCa in patients who underwent surgery by being diagnosed with benign prostatic hyperplasia (BPH) clinically or by standard prostate biopsy.
Data of 317 patients, who underwent transurethral resection of the prostate (TURP) or open prostatectomy (OP) with pre-diagnosis of BPH, were evaluated retrospectively. The examined parameters included patients' demographics, preoperative serum PSA values, digital rectal examination (DRE) findings, surgical method, histopathological findings and Gleason Scores.
A total of 317 patients were included the study. The median age of patients was 69 years (min: 51-max: 79) and the median PSA value was 3.24 ng/dl (min: 0.17-max: 34.9). In 21 patients (6.6%); DRE findings were in favor of malignancy, but prostate biopsy resulted as BPH. While 281 (88.6%) of the patients underwent TURP, 36 (11.4%) underwent open prostatectomy. PCa was detected in 21 (6.6%) patients. PSA was statistically higher in patients who underwent OP compared to patient who underwent TUR-P, 5.9 (min: 1.2 - max: 27.6, IR: 8.7) vs. 2.8 (min: 0.1-max: 34.9, IR: 4.2) ng/dl, p < .001. The rate of IPCa among four PSA group was similar (p = 0.46). There was no difference between the rate of IPCa in patients younger and older than 70 years, (p = 0.11). Please change whole sentence as 'The median PSA level was slightly higher in patients diagnosed with BPH compared to patients diagnosed with IPCa, 3.2 (min: 0.1-max: 34.9) vs. 2.7 (min: 0.3-max: 26.5) ng/dL, p = 0.9.
IPCa still remains an important clinical problem. We were not able to find any correlation of PSA and age with incidental PCa.
研究经临床诊断为良性前列腺增生（BPH）或经标准前列腺活检诊断为良性前列腺增生（BPH）患者手术中偶然发现的前列腺癌（IPCa）发生率，并确定提示前列腺癌（PCa）的前列腺特异性抗原（PSA）截断值。
回顾性分析 317 例经尿道前列腺电切术（TURP）或开放性前列腺切除术（OP）的患者资料。检查参数包括患者的人口统计学资料、术前血清 PSA 值、直肠指检（DRE）结果、手术方法、组织病理学结果和 Gleason 评分。
共有 317 例患者纳入研究。患者的中位年龄为 69 岁（最小：51-最大：79），中位 PSA 值为 3.24ng/dl（最小：0.17-最大：34.9）。21 例患者（6.6%）；DRE 检查结果倾向于恶性，但前列腺活检结果为 BPH。281 例患者（88.6%）接受 TURP 治疗，36 例（11.4%）接受开放性前列腺切除术。21 例（6.6%）患者发现前列腺癌。与接受 TURP 治疗的患者相比，接受 OP 治疗的患者 PSA 水平更高，分别为 5.9（最小：1.2-最大：27.6，IR：8.7）和 2.8（最小：0.1-最大：34.9，IR：4.2）ng/dl，p<0.001。四个 PSA 组的 IPCa 发生率相似（p=0.46）。70 岁以上和 70 岁以下患者的 IPCa 发生率无差异（p=0.11）。
偶然发现的前列腺癌仍然是一个重要的临床问题。我们未能发现 PSA 与年龄与偶然发现的前列腺癌之间存在任何相关性。
