• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

PTEN 和 ERG 重排对局限性前列腺癌的临床影响。

Clinical impact of combined PTEN and ERG rearrangements in localized prostate cancer.

机构信息

Urology Department, General Hospital of Athens "G. Gennimatas", Athens.

1st Department of Urology, School of Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens.

出版信息

Arch Ital Urol Androl. 2021 Mar 19;93(1):84-85. doi: 10.4081/aiua.2021.1.84.

DOI:10.4081/aiua.2021.1.84
PMID:33754616
Abstract

To the Editor, Prostate cancer (PCa) is nowadays the second most common malignancy diagnosed among men and is responsible for one of the leading causes of cancer mortality. Clinically localized disease may present with a wide variety of clinical behavior including tumors of low clinical significance as well as highly aggressive ones. Among patients treated with either radical prostatectomy or radiotherapy there is a risk of biochemical failure (BF). As a result, it is of outmost interest to develop new markers predicting the risk of BF development.

摘要

致编辑,前列腺癌(PCa)是目前男性中诊断出的第二大常见恶性肿瘤,也是癌症死亡的主要原因之一。临床局限性疾病可能表现出多种不同的临床行为,包括临床意义较低的肿瘤和高度侵袭性肿瘤。在接受根治性前列腺切除术或放疗的患者中,存在生化失败(BF)的风险。因此,开发新的标志物来预测 BF 发展的风险至关重要。

相似文献

1
Clinical impact of combined PTEN and ERG rearrangements in localized prostate cancer.PTEN 和 ERG 重排对局限性前列腺癌的临床影响。
Arch Ital Urol Androl. 2021 Mar 19;93(1):84-85. doi: 10.4081/aiua.2021.1.84.
2
Association of ERG/PTEN status with biochemical recurrence after radical prostatectomy for clinically localized prostate cancer.ERG/PTEN 状态与局限性前列腺癌根治术后生化复发的相关性。
Med Oncol. 2018 Oct 5;35(12):152. doi: 10.1007/s12032-018-1212-6.
3
PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer.PTEN 基因缺失是前列腺癌中与 ERG 基因重排相关的早期事件。
BJU Int. 2011 Feb;107(3):477-85. doi: 10.1111/j.1464-410X.2010.09470.x.
4
Concurrent TMPRSS2-ERG and SLC45A3-ERG rearrangements plus PTEN loss are not found in low grade prostate cancer and define an aggressive tumor subset.在低级别前列腺癌中未发现同时存在的TMPRSS2-ERG和SLC45A3-ERG重排以及PTEN缺失,它们定义了一个侵袭性肿瘤亚组。
Prostate. 2016 Jun;76(9):854-65. doi: 10.1002/pros.23176. Epub 2016 Mar 9.
5
SPINK1 Overexpression in Localized Prostate Cancer: a Rare Event Inversely Associated with ERG Expression and Exclusive of Homozygous PTEN Deletion.SPINK1在局限性前列腺癌中的过表达:一种与ERG表达呈负相关且排除纯合性PTEN缺失的罕见事件。
Pathol Oncol Res. 2017 Apr;23(2):399-407. doi: 10.1007/s12253-016-0119-9. Epub 2016 Oct 13.
6
The impact of PTEN deletion and ERG rearrangement on recurrence after treatment for prostate cancer: a systematic review and meta-analysis.PTEN 缺失和 ERG 重排对前列腺癌治疗后复发的影响:系统评价和荟萃分析。
Clin Transl Oncol. 2020 May;22(5):694-702. doi: 10.1007/s12094-019-02170-3. Epub 2019 Jul 29.
7
Clinical impact of ERG and PTEN status in prostate cancer patients underwent radical prostatectomy.ERG 和 PTEN 状态对行根治性前列腺切除术的前列腺癌患者的临床影响。
Arch Ital Urol Androl. 2022 Dec 27;94(4):390-395. doi: 10.4081/aiua.2022.4.390.
8
ERG rearrangement is associated with prostate cancer-related death in Chinese prostate cancer patients.在中国前列腺癌患者中,ERG重排与前列腺癌相关死亡有关。
PLoS One. 2014 Feb 7;9(2):e84959. doi: 10.1371/journal.pone.0084959. eCollection 2014.
9
Loss of KLK4::KLKP1 pseudogene expression by RNA chromogenic in-situ hybridization is associated with PTEN loss and increased risk of biochemical recurrence in a cohort of middle eastern men with prostate cancer.通过 RNA 显色原位杂交检测 KLK4::KLKP1 假基因表达缺失与中东男性前列腺癌患者 PTEN 缺失及生化复发风险增加相关。
J Cancer Res Clin Oncol. 2023 Jul;149(7):3721-3728. doi: 10.1007/s00432-022-04279-5. Epub 2022 Aug 18.
10
Interactions and relationships of PTEN, ERG, SPINK1 and AR in castration-resistant prostate cancer.PTEN、ERG、SPINK1 和 AR 在去势抵抗性前列腺癌中的相互作用和关系。
Histopathology. 2012 Mar;60(4):645-52. doi: 10.1111/j.1365-2559.2011.04116.x. Epub 2012 Jan 19.

引用本文的文献

1
Serrate RNA Effector Molecule (SRRT) Is Associated with Prostate Cancer Progression and Is a Predictor of Poor Prognosis in Lethal Prostate Cancer.锯齿状RNA效应分子(SRRT)与前列腺癌进展相关,是致命性前列腺癌预后不良的一个预测指标。
Cancers (Basel). 2023 May 22;15(10):2867. doi: 10.3390/cancers15102867.
2
ARPC1B Is Associated with Lethal Prostate Cancer and Its Inhibition Decreases Cell Invasion and Migration In Vitro.ARPC1B 与致命性前列腺癌相关,其抑制作用可降低体外细胞侵袭和迁移。
Int J Mol Sci. 2022 Jan 27;23(3):1476. doi: 10.3390/ijms23031476.