缺乏HLA I类等位基因的白细胞可预测获得性再生障碍性贫血患者向骨髓增生异常综合征/急性髓系白血病的罕见克隆进化。 - Suppr

HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.

作者信息

Hosokawa Kohei, Mizumaki Hiroki, Yoroidaka Takeshi, Maruyama Hiroyuki, Imi Tatsuya, Tsuji Noriaki, Urushihara Ryota, Tanabe Mikoto, Zaimoku Yoshitaka, Nguyen Mai Anh Thi, Tran Dung Cao, Ishiyama Ken, Yamazaki Hirohito, Katagiri Takamasa, Takamatsu Hiroyuki, Hosomichi Kazuyoshi, Tajima Atsushi, Azuma Fumihiro, Ogawa Seishi, Nakao Shinji

机构信息

Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Division of Transfusion Medicine, Kanazawa University Hospital, Kanazawa, Japan.

出版信息

Blood. 2021 Jun 24;137(25):3576-3580. doi: 10.1182/blood.2020010586.

DOI:10.1182/blood.2020010586

PMID:33754630

Abstract

摘要

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HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.

作者信息

机构信息

Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Division of Transfusion Medicine, Kanazawa University Hospital, Kanazawa, Japan.

出版信息

Blood. 2021 Jun 24;137(25):3576-3580. doi: 10.1182/blood.2020010586.

DOI:10.1182/blood.2020010586

PMID:33754630

Abstract

摘要

相似文献

HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.

Blood. 2021 Jun 24;137(25):3576-3580. doi: 10.1182/blood.2020010586.

Significance of Clonal Mutations in Bone Marrow Failure and Inherited Myelodysplastic Syndrome/Acute Myeloid Leukemia Predisposition Syndromes.

Hematol Oncol Clin North Am. 2018 Aug;32(4):643-655. doi: 10.1016/j.hoc.2018.03.005. Epub 2018 May 1.

Clonal selection in therapy-related myelodysplastic syndromes and acute myeloid leukemia under azacitidine treatment.

Eur J Haematol. 2020 May;104(5):488-498. doi: 10.1111/ejh.13390. Epub 2020 Mar 9.

N-RAS gene mutation in patients with aplastic anemia and aplastic anemia/ paroxysmal nocturnal hemoglobinuria during evolution to clonal disease.

Blood. 2000 Jan 15;95(2):646-50.

Clinical impact of dysplastic changes in acquired aplastic anemia: A systematic study of bone marrow biopsies in children and adults.

Ann Diagn Pathol. 2020 Apr;45:151459. doi: 10.1016/j.anndiagpath.2019.151459. Epub 2019 Dec 30.

Transformation of myelodysplastic syndromes into acute myeloid leukemias.

Chin Med J (Engl). 2004 Jul;117(7):963-7.

Cytogenetic clonal evolution in myelodysplastic syndromes is associated with inferior prognosis.

Cancer. 2017 Dec 1;123(23):4608-4616. doi: 10.1002/cncr.30917. Epub 2017 Jul 26.

Hematol Oncol. 2020 Oct;38(4):531-540. doi: 10.1002/hon.2755. Epub 2020 Jun 24.

HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation.

Biol Blood Marrow Transplant. 2011 Jun;17(6):885-92. doi: 10.1016/j.bbmt.2010.09.012. Epub 2010 Sep 24.

A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl.

Leuk Lymphoma. 2017 Mar;58(3):718-721. doi: 10.1080/10428194.2016.1207765. Epub 2016 Nov 28.

引用本文的文献

Romiplostim with ciclosporin A in patients with aplastic anaemia naïve to immunosuppressive therapy: A phase 2/3 study.

Br J Haematol. 2025 Aug;207(2):582-590. doi: 10.1111/bjh.20206. Epub 2025 Jul 10.

Hypomethylating agents are associated with high rates of hematologic toxicity in patients with secondary myeloid neoplasms developing after acquired aplastic anemia.

Haematologica. 2024 Aug 1;109(8):2732-2737. doi: 10.3324/haematol.2024.285275.

Comparison of human leukocyte antigen in patients with paroxysmal nocturnal hemoglobinuria of different clone sizes.

Ann Hematol. 2024 Jun;103(6):1897-1907. doi: 10.1007/s00277-024-05740-w. Epub 2024 Apr 15.

Diagnosis of immune pathophysiology in patients with bone marrow failure.

Int J Hematol. 2024 Mar;119(3):231-239. doi: 10.1007/s12185-022-03519-1. Epub 2023 Jan 7.

Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities.

JCI Insight. 2022 Nov 22;7(22):e163040. doi: 10.1172/jci.insight.163040.

Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia.

Leukemia. 2022 Sep;36(9):2328-2337. doi: 10.1038/s41375-022-01636-8. Epub 2022 Jul 27.

Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15.

Leukemia. 2022 Jun;36(6):1666-1675. doi: 10.1038/s41375-022-01549-6. Epub 2022 Apr 26.

HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.

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HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.

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