Scelfo C, Mantagos I S
Department of Ophthalmology, Boston Children's Hospital, Boston, MA, USA.
Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Semin Ophthalmol. 2021 May 19;36(4):289-295. doi: 10.1080/08820538.2021.1896747. Epub 2021 Mar 23.
: This review provides an overview of the causes and treatment of neurotrophic keratopathy in the pediatric population.: A thorough review of the current literature discussing neurotrophic keratopathy was conducted then summarized.Fourty-nine papers were reviewed. Congenital and acquired causes of neurotrophic keratopathy exist in the pediatric population. Both medical and surgical approaches to treatment have been trialed, albeit to a limited extent, in pediatric patients. Conservative treatment includes topical lubrication and antibiotics to prevent concurrent infectious ulcer formation. Various neurotrophic factors have been trialed in the form of serum drops to restore corneal sensation when conservative measures fail. Surgically, different corneal neurotization techniques have been developed whereby a donor nerve is routed to the anesthetized cornea to restore innervation and sensation. : Advances in the treatment of neurotrophic keratopathy have made corneal reinnervation and restoration of vision more easily attainable in pediatric patients.
本综述概述了儿童群体中神经营养性角膜病变的病因及治疗方法。对当前讨论神经营养性角膜病变的文献进行了全面回顾并总结。共查阅了49篇论文。儿童群体中存在神经营养性角膜病变的先天性和后天性病因。治疗方法包括药物治疗和手术治疗，尽管在儿科患者中的应用有限。保守治疗包括局部润滑和使用抗生素以预防并发感染性溃疡形成。当保守措施无效时，已尝试以血清滴剂的形式使用各种神经营养因子来恢复角膜感觉。在手术方面，已开发出不同的角膜神经化技术，即将供体神经连接到麻醉的角膜以恢复神经支配和感觉。神经营养性角膜病变治疗方法的进展使儿科患者更容易实现角膜再神经化和视力恢复。
