Giannaccare Giuseppe, Lucisano Andrea, Pellegrini Marco, Scuteri Gianfranco, Mancini Alessandra, Malaventura Cristina, Busin Massimo, Scorcia Vincenzo
Department of Ophthalmology, University Magna Græcia of Catanzaro, Catanzaro, Italy.
Department of Ophthalmology, Ospedali Privati Forlì"Villa Igea", Forlì, Italy.
Am J Ophthalmol Case Rep. 2022 Feb 18;26:101446. doi: 10.1016/j.ajoc.2022.101446. eCollection 2022 Jun.
To report the feasibility and the successful outcomes of a pediatric neurotrophic keratopathy (NK) owing to congenital corneal anesthesia (CCA) treated with allogeneic serum eye drops obtained from the mother as the only therapy.
A 18-month-old girl with generalized pain insensitivity presented with a large epithelial defect in the right eye (RE) and superficial punctate keratopathy (SPK) in the left eye (LE). Corneal sensitivity was completely absent in both eyes (BE). Peripheral serum eye drops obtained from the mother was prescribed and administered every 2 hours in BE. Two weeks after the beginning of treatment, compete healing of the epithelial defect in the RE was obtained, while the severity of the SPK in the LE markedly improved; in parallel, conjunctival hyperemia disappeared in BE. The treatment was continued over the course of 3 months with good tolerability and neither signs of recurrence of the epithelial defect nor other complications were noted.
Allogeneic serum eye drops obtained from the mother are effective in treating pediatric NK owing to CCA. This treatment may represent a readily available and inexpensive option when topical nerve growth factor is unavailable or corneal neurotization is not feasible.
报告以母亲提供的异体血清滴眼液作为唯一治疗方法，治疗因先天性角膜麻醉（CCA）导致的小儿神经营养性角膜病变（NK）的可行性及成功结果。
一名18个月大的女童存在全身疼痛不敏感，右眼出现大的上皮缺损，左眼出现浅层点状角膜炎（SPK）。双眼角膜敏感性完全缺失。开具了从母亲处获取的外周血清滴眼液，并每2小时双眼给药一次。治疗开始两周后，右眼上皮缺损完全愈合，而左眼SPK的严重程度明显改善；同时，双眼结膜充血消失。治疗持续3个月，耐受性良好，未观察到上皮缺损复发迹象或其他并发症。
母亲提供的异体血清滴眼液治疗因CCA导致的小儿NK有效。当局部神经生长因子不可用或角膜神经化不可行时，这种治疗可能是一种容易获得且廉价的选择。
