靶向多发性硬化症的血清素能系统：发病机制治疗的前景。
Serotoninergic system targeting in multiple sclerosis: the prospective for pathogenetic therapy.
机构信息
Department of Neuroimmunology, Federal Center of Brain research and Neurotechnology of the Federal Medical-Biological Agency of Russia; Department of Neurology, Neurosurgery and Medical Genetics and Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University, Moscow, Russia; Laboratory of Clinical Immunology, National Research Center Institute of Immunology of the Federal Medical-Biological Agency of Russia, Moscow, Russia.
Department of Neuroimmunology, Federal Center of Brain research and Neurotechnology of the Federal Medical-Biological Agency of Russia; Department of Neurology, Neurosurgery and Medical Genetics and Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University, Moscow, Russia.
出版信息
Mult Scler Relat Disord. 2021 Jun;51:102888. doi: 10.1016/j.msard.2021.102888. Epub 2021 Mar 10.
Serotonin (5-hydroxytryptamine) (5-HT) is a neurotransmitter, which mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of 5-HT on gut microbiota functions, which play an essential role in developing CNS inflammatory diseases. Finally, 5-HT is a direct mediator of neuroimmune interaction. The article reviews the literature data on the role of 5-HT in the regulation of neuroinflammation in multiple sclerosis (MS). The influence of 5-HT and selective serotonin reuptake inhibitors (SSRIs) on experimental autoimmune encephalomyelitis (EAE) and MS pathogenesis, as well as the therapeutic potential of serotoninergic drugs as a pathogenetic therapy of MS, are discussed.
血清素（5-羟色胺）（5-HT）是一种神经递质，可调节中枢神经系统（CNS）的神经心理功能。最近的研究表明，5-HT 对肠道微生物群功能具有调节作用，而后者对于中枢神经系统炎症性疾病的发展至关重要。最后，5-HT 是神经免疫相互作用的直接介质。本文综述了关于 5-HT 在多发性硬化症（MS）中神经炎症调节作用的文献数据。讨论了 5-HT 和选择性 5-羟色胺再摄取抑制剂（SSRIs）对实验性自身免疫性脑脊髓炎（EAE）和 MS 发病机制的影响，以及作为 MS 病因治疗的 5-羟色胺能药物的治疗潜力。
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