白塞病与多发性硬化症和类风湿性关节炎相关：一项韩国基于人群的研究。

Behçet's Disease Is Associated with Multiple Sclerosis and Rheumatoid Arthritis: A Korean Population-Based Study.

机构信息

Department of Biomedicine and Health Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea.

Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.

出版信息

Dermatology. 2022;238(1):86-91. doi: 10.1159/000514634. Epub 2021 Mar 23.

DOI:10.1159/000514634

PMID:33756455

Abstract

BACKGROUND

No epidemiologic study has previously reported on the associations among Behçet's disease (BD) and autoimmune disorders.

OBJECTIVES

To investigate the association between BD and the autoimmune disorders multiple sclerosis and rheumatoid arthritis.

METHODS

Medical records of patients newly diagnosed with BD (n = 6,214) in 2012-2017 were analyzed using data entered into a large, nationwide database from 2007 to 2017. An age- and sex-matched control population of individuals without BD was sampled at a ratio of controls:BD cases of 3:1 (n = 18,642). Both cohorts were analyzed for the presence of multiple sclerosis or rheumatoid arthritis within a minimum of 5 years prior to their BD diagnosis.

RESULTS

Patients with BD had significantly higher odds ratios (ORs) for multiple sclerosis (8.85 [95% CI 2.36-33.17]) and rheumatoid arthritis (4.62 [95% CI 3.35-6.35]) than the control group after adjustment for diabetes mellitus, hypertension, and dyslipidemia. BD patients aged <40 years had a higher proportion of rheumatoid arthritis (OR 23.91, 95% CI 5.50-103.9) than older patients (OR 3.96, 95% CI 2.83-5.54).

CONCLUSION

Our results suggest that BD is associated with multiple sclerosis and rheumatoid arthritis.

摘要

背景

以前没有流行病学研究报告过贝切特病（BD）与自身免疫性疾病之间的关联。

目的

研究 BD 与多发性硬化症和类风湿关节炎等自身免疫性疾病之间的关联。

方法

分析了 2012 年至 2017 年期间新诊断为 BD（n=6214）的患者的病历，这些数据是从 2007 年至 2017 年输入到一个大型全国性数据库中的。按照对照：BD 病例 3:1 的比例（n=18642），从无 BD 的个体中抽取年龄和性别匹配的对照人群。在 BD 诊断前至少 5 年，对两组人群进行多发性硬化症或类风湿关节炎的存在情况进行分析。

结果

调整糖尿病、高血压和血脂异常后，BD 患者发生多发性硬化症的比值比（OR）显著高于对照组（8.85[95%CI 2.36-33.17]）和类风湿关节炎（OR 4.62[95%CI 3.35-6.35]）。年龄<40 岁的 BD 患者发生类风湿关节炎的比例（OR 23.91，95%CI 5.50-103.9）高于年龄较大的患者（OR 3.96，95%CI 2.83-5.54）。