Annoni G, Donato M F, Cantaluppi C, Lampertico P, Cargnel A, Viganò P, Hahn E G, Colombo M
Istituto di Medicina Interna, Università degli Studi di Milano.
Ric Clin Lab. 1988 Jan-Mar;18(1):37-44. doi: 10.1007/BF02918817.
Serum levels of procollagen type III peptide were measured by radioimmunoassay in 76 consecutive patients with acute viral hepatitis, in order to see if this index of hepatic fibrogenesis is also predictive for the development of chronic active hepatitis in high-risk patients. Serum procollagen levels were high (from 14.2 to 109.2 ng/ml, median 33.7 ng/ml) in 74 (97%) patients and normal (from 4 to 14 ng/ml, median 9.1 ng/ml) in 2 (3%) patients. The baseline serum procollagen levels were similar in all the subgroups of patients independently of the type of hepatitis. In the 59 patients with resolving hepatitis, serum procollagen levels returned to normal values from 2 to 48 weeks (mean 15). In the 17 patients with unresolved hepatitis, procollagen levels remained within the normal limits in 6 of 7 patients with non-progressive chronic disease, while were elevated (from 17.4 to 22.2 ng/ml) in 4 of 5 patients with chronic active hepatitis. Unlike transaminase activity, which could not discriminate between benign and progressive liver disease, serum levels of procollagen helped in identifying patients with unresolved hepatitis, who were developing chronic active disease.
采用放射免疫分析法对76例连续的急性病毒性肝炎患者检测血清III型前胶原肽水平，以观察该肝纤维化指标是否也能预测高危患者慢性活动性肝炎的发生。74例（97%）患者血清前胶原水平较高（14.2至109.2 ng/ml，中位数33.7 ng/ml），2例（3%）患者正常（4至14 ng/ml，中位数9.1 ng/ml）。无论肝炎类型如何，所有患者亚组的基线血清前胶原水平相似。在59例肝炎病情缓解的患者中，血清前胶原水平在2至48周（平均15周）恢复至正常水平。在17例肝炎病情未缓解的患者中，7例非进行性慢性疾病患者中有6例前胶原水平保持在正常范围内，而5例慢性活动性肝炎患者中有4例前胶原水平升高（17.4至22.2 ng/ml）。与无法区分良性和进行性肝病的转氨酶活性不同，血清前胶原水平有助于识别肝炎病情未缓解且正在发展为慢性活动性疾病的患者。
