Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
J Thorac Cardiovasc Surg. 2022 Dec;164(6):1755-1766.e16. doi: 10.1016/j.jtcvs.2021.01.028. Epub 2021 Jan 23.
To evaluate recent practice and outcomes of reoperative cardiac surgery via re-sternotomy. Use of early versus late institution of cardiopulmonary bypass (CPB) before sternal re-entry was of particular interest.
From January 2008 to July 2017, 7640 patients underwent reoperative cardiac surgery at Cleveland Clinic. The study group consisted of 6627 who had a re-sternotomy and preoperative computed tomography scans; 755 and 5872 were in the early and late institution of CPB groups, respectively. Patients were stratified into high (n = 563) or low (n = 6064) anatomic risk of re-entry on the basis of computed tomography criteria. Weighted propensity-balanced operative mortality and morbidity were compared with surgeon as a random effect.
Reoperative procedures most commonly incorporated aortic valve replacement (n = 3611) and coronary artery bypass grafting (n = 2029), but also aortic root (n = 1061) and arch procedures (n = 527). Unadjusted operative mortality was 3.5% (235/6627), and major sternal re-entry and mediastinal dissection injuries were uncommon (2.8%). In the propensity-weighted analysis, similar mortality (3.1% vs 4.5%; P = .6) and major morbidity, including stroke (1.8% vs 3.2%) and dialysis (0 vs 2.6%), were noted in the high anatomic risk cohort between early and late CPB groups. Similar trends were observed in the low anatomic risk cohort (mortality 3.5% vs 2.1%; P = .2).
Reoperative cardiac surgery is associated with low operative morbidity and mortality at an experienced center. Early and late CPB strategies have comparable outcomes in the context of an image-guided, team-based strategy.
评估经胸骨再切开行再次心脏手术的近期实践和结果。特别关注在胸骨重新进入前早期与晚期使用体外循环(CPB)的情况。
2008 年 1 月至 2017 年 7 月,克利夫兰诊所共有 7640 例患者接受了再次心脏手术。研究组由 6627 例接受胸骨再切开术和术前计算机断层扫描的患者组成;其中 755 例和 5872 例分别在早期和晚期建立 CPB 组。根据 CT 标准,将患者分为高(n=563)或低(n=6064)胸骨再切开解剖风险。使用外科医生作为随机效应,比较加权倾向平衡后的手术死亡率和发病率。
再次手术最常见的是主动脉瓣置换术(n=3611)和冠状动脉旁路移植术(n=2029),但也有主动脉根部(n=1061)和弓部手术(n=527)。未调整的手术死亡率为 3.5%(235/6627),主要胸骨再切开和纵隔切开损伤并不常见(2.8%)。在倾向评分加权分析中,高解剖风险组中,早期与晚期 CPB 组之间的死亡率(3.1%比 4.5%;P=0.6)和主要发病率,包括中风(1.8%比 3.2%)和透析(0 比 2.6%)相似。在低解剖风险组中也观察到类似的趋势(死亡率 3.5%比 2.1%;P=0.2)。
在有经验的中心,再次心脏手术的手术发病率和死亡率较低。在基于图像引导的团队策略中,早期和晚期 CPB 策略的结果相似。