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现代心脏再手术的实践与结果。

Modern practice and outcomes of reoperative cardiac surgery.

机构信息

Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

出版信息

J Thorac Cardiovasc Surg. 2022 Dec;164(6):1755-1766.e16. doi: 10.1016/j.jtcvs.2021.01.028. Epub 2021 Jan 23.

Abstract

OBJECTIVES

To evaluate recent practice and outcomes of reoperative cardiac surgery via re-sternotomy. Use of early versus late institution of cardiopulmonary bypass (CPB) before sternal re-entry was of particular interest.

METHODS

From January 2008 to July 2017, 7640 patients underwent reoperative cardiac surgery at Cleveland Clinic. The study group consisted of 6627 who had a re-sternotomy and preoperative computed tomography scans; 755 and 5872 were in the early and late institution of CPB groups, respectively. Patients were stratified into high (n = 563) or low (n = 6064) anatomic risk of re-entry on the basis of computed tomography criteria. Weighted propensity-balanced operative mortality and morbidity were compared with surgeon as a random effect.

RESULTS

Reoperative procedures most commonly incorporated aortic valve replacement (n = 3611) and coronary artery bypass grafting (n = 2029), but also aortic root (n = 1061) and arch procedures (n = 527). Unadjusted operative mortality was 3.5% (235/6627), and major sternal re-entry and mediastinal dissection injuries were uncommon (2.8%). In the propensity-weighted analysis, similar mortality (3.1% vs 4.5%; P = .6) and major morbidity, including stroke (1.8% vs 3.2%) and dialysis (0 vs 2.6%), were noted in the high anatomic risk cohort between early and late CPB groups. Similar trends were observed in the low anatomic risk cohort (mortality 3.5% vs 2.1%; P = .2).

CONCLUSIONS

Reoperative cardiac surgery is associated with low operative morbidity and mortality at an experienced center. Early and late CPB strategies have comparable outcomes in the context of an image-guided, team-based strategy.

摘要

目的

评估经胸骨再切开行再次心脏手术的近期实践和结果。特别关注在胸骨重新进入前早期与晚期使用体外循环(CPB)的情况。

方法

2008 年 1 月至 2017 年 7 月,克利夫兰诊所共有 7640 例患者接受了再次心脏手术。研究组由 6627 例接受胸骨再切开术和术前计算机断层扫描的患者组成;其中 755 例和 5872 例分别在早期和晚期建立 CPB 组。根据 CT 标准,将患者分为高(n=563)或低(n=6064)胸骨再切开解剖风险。使用外科医生作为随机效应,比较加权倾向平衡后的手术死亡率和发病率。

结果

再次手术最常见的是主动脉瓣置换术(n=3611)和冠状动脉旁路移植术(n=2029),但也有主动脉根部(n=1061)和弓部手术(n=527)。未调整的手术死亡率为 3.5%(235/6627),主要胸骨再切开和纵隔切开损伤并不常见(2.8%)。在倾向评分加权分析中,高解剖风险组中,早期与晚期 CPB 组之间的死亡率(3.1%比 4.5%;P=0.6)和主要发病率,包括中风(1.8%比 3.2%)和透析(0 比 2.6%)相似。在低解剖风险组中也观察到类似的趋势(死亡率 3.5%比 2.1%;P=0.2)。

结论

在有经验的中心,再次心脏手术的手术发病率和死亡率较低。在基于图像引导的团队策略中,早期和晚期 CPB 策略的结果相似。

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