School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Institute of Advanced Studies, University of São Paulo, São Paulo, Brazil.
Thorax. 2021 Oct;76(10):962-969. doi: 10.1136/thoraxjnl-2020-216549. Epub 2021 Mar 23.
Both cold and hot temperature have been associated with the onset of asthma, but it remains largely unknown about the risk of asthma hospitalisation associated with short-term temperature fluctuation or temperature variability (TV).
To explore the association between short-term exposure to TV and asthma hospitalisation in Brazil.
Data for asthma hospitalisation and weather conditions were collected from 1816 Brazilian cities between 2000 and 2015. TV was calculated as the SD of all daily minimum and maximum temperatures within 0-7 days prior to current day. A time-stratified case-crossover design was performed to quantify the association between TV and hospitalisation for asthma.
A total of 2 818 911 hospitalisations for asthma were identified during the study period. Each 1°C increase in 0-7 days' TV exposure was related to a 1.0% (95% CI 0.7% to 1.4%) increase in asthma hospitalisations. The elderly were more vulnerable to TV than other age groups, while region and season appeared to significantly modify the associations. There were 159 305 (95% CI 55 293 to 2 58 054) hospitalisations, US$48.41 million (95% CI US$16.92 to US$78.30 million) inpatient costs at 2015 price and 450.44 thousand inpatient days (95% CI 156.08 to 729.91 thousand days) associated with TV during the study period. The fraction of asthma hospitalisations attributable to TV increased from 5.32% in 2000 to 5.88% in 2015.
TV was significantly associated with asthma hospitalisation and the corresponding substantial health costs in Brazil. Our findings suggest that preventive measures of asthma should take TV into account.
低温和高温都与哮喘的发作有关，但短期温度波动或温度变异性（TV）与哮喘住院风险之间的关系在很大程度上仍不清楚。
探讨巴西短期暴露于 TV 与哮喘住院之间的关系。
本研究收集了 2000 年至 2015 年间巴西 1816 个城市的哮喘住院和天气数据。TV 被计算为当前日之前 0-7 天内所有每日最低和最高温度的标准差。采用时间分层病例交叉设计来量化 TV 与哮喘住院之间的关联。
在研究期间，共发现 2818911 例哮喘住院。0-7 天 TV 暴露每增加 1°C，哮喘住院率增加 1.0%（95%CI 0.7%至 1.4%）。与其他年龄组相比，老年人更容易受到 TV 的影响，而区域和季节似乎显著改变了这种关联。在研究期间，有 159305 例（95%CI 55293 至 258054 例）哮喘住院，2015 年价格下 4841 万美元（95%CI 1692 万美元至 7830 万美元）住院费用，450.44 千天（95%CI 156.08 千天至 729.91 千天）与 TV 相关。2000 年，归因于 TV 的哮喘住院比例为 5.32%，2015 年增加到 5.88%。
TV 与巴西哮喘住院率及相应的大量卫生费用显著相关。我们的研究结果表明，哮喘的预防措施应考虑 TV。
