Lee Moon Young, Kim Eui Joong, Shin Aesun, Kim Yong Sung
Department of Physiology, Wonkwang Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2021 Mar 25;77(3):104-114. doi: 10.4166/kjg.2021.020.
Men and women are different, but this difference has not been well reflected in clinical trials and preclinical studies of biomedical science. Gender medicine, which systematically analyzes research results according to sex and gender, has been emphasized to overcome this problem. On the other hand, researchers still have difficulty in applying gender medicine to their research. To perform rigorous gender medicine, using correct terms, a thorough literature review during research planning, appropriate statistical analysis and reporting, and cautious interpretation of the results are necessary. Applying gender medicine will increase the reproducibility of studies, promote discoveries, expand the study relevance, and ultimately improve patient care in both men and women. Here, this study reviewed the practical issues on applying gender medicine to both preclinical and clinical studies in the field of biomedical science.
男性和女性存在差异，但这种差异在生物医学科学的临床试验和临床前研究中并未得到充分体现。强调根据性别系统分析研究结果的性别医学，旨在克服这一问题。另一方面，研究人员在将性别医学应用于其研究时仍存在困难。为了严谨地开展性别医学研究，使用正确的术语、在研究规划过程中进行全面的文献综述、进行适当的统计分析和报告以及谨慎地解读结果是必要的。应用性别医学将提高研究的可重复性、促进发现、扩大研究的相关性，并最终改善男性和女性患者的护理。在此，本研究回顾了在生物医学科学领域将性别医学应用于临床前和临床研究的实际问题。
