Yamazaki K, Beauchamp G K, Kupniewski D, Bard J, Thomas L, Boyse E A
Monell Chemical Senses Center, Philadelphia, PA 19104.
Science. 1988 Jun 3;240(4857):1331-2. doi: 10.1126/science.3375818.
Inbred male mice typically prefer to mate with females of a different, non-self H-2 haplotype. To determine whether this natural preference is irrevocable or results from familial imprinting, a test system was used which relied on previous observations that B6 males (H-2b) mate preferentially with congenic B6-H-2k rather than B6 females, and B6-H-2k males with B6 females. This preference was reversed in B6 males fostered by B6-H-2k parents and in B6-H-2k males fostered by B6 parents, preference in these cases favoring the same H-2 type. Thus, H-2 selective mating preference is acquired by imprinting on familial H-2 types.
近交系雄性小鼠通常更喜欢与具有不同非自身H-2单倍型的雌性小鼠交配。为了确定这种自然偏好是不可改变的，还是由家族印记导致的，使用了一种测试系统，该系统依赖于先前的观察结果，即B6雄性小鼠（H-2b）优先与同基因的B6-H-2k雌性小鼠交配，而不是B6雌性小鼠，B6-H-2k雄性小鼠则与B6雌性小鼠交配。在由B6-H-2k亲本抚养的B6雄性小鼠和由B6亲本抚养的B6-H-2k雄性小鼠中，这种偏好发生了逆转，在这些情况下，偏好相同的H-2类型。因此，H-2选择性交配偏好是通过对家族H-2类型的印记获得的。
