使用非侵入性加速计方法诊断早产儿胃食管反流。

Use of a non-invasive accelerometric method for diagnosing gastroesophageal reflux in premature infants.

机构信息

Division of Neonatology, Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI, USA.

出版信息

J Perinatol. 2021 Aug;41(8):1879-1885. doi: 10.1038/s41372-021-01034-5. Epub 2021 Mar 23.

DOI:10.1038/s41372-021-01034-5

PMID:33758392

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8342305/

Abstract

OBJECTIVE

To evaluate the clinical usefulness of a non-invasive accelerometric device to diagnose GER in preterm babies.

STUDY DESIGN

An accelerometer was taped over the sub-xiphoid process in 110 preterm (GA 29.6 ± 3.3 wk) infants (133 studies). Low frequency, sub-audible signals were captured via digital recording (sampling rate 200 Hz), then re-sampled (rate = 60 Hz) to create a spectrogram (focused range 0-30 Hz). Mean amplitude in the focused range was calculated.

RESULTS

Of 85 studies with simultaneous pH-metry and accelerometry, 18 had concurrent positive and 23 had concurrent negative scores, 42 had negative pH scores when accelerometry was positive (≥1 µV), consistent with non-acid reflux. Eleven infants at high risk of aspiration received surgical interventions. All but 1 had negative pH scores while 10/11 had positive accelerometry.

CONCLUSIONS

The non-invasiveness of this accelerometric technique allows for GER screening and for repeated testing to assess efficacy of interventions.

摘要

目的

评估一种非侵入性加速计设备在诊断早产儿胃食管反流（GER）中的临床应用价值。

研究设计

将加速度计贴在 110 名早产儿（GA 29.6±3.3 周）的剑突下（SUB），共进行了 133 次研究。通过数字记录（采样率 200Hz）捕获低频、次声信号，然后重新采样（速率=60Hz）以创建频谱图（聚焦范围 0-30Hz）。计算聚焦范围内的平均幅度。

结果

在 85 项同时进行 pH 测量和加速度计检测的研究中，18 项同时存在阳性和 23 项同时存在阴性评分，42 项当加速度计阳性（≥1µV）时 pH 评分阴性，与非酸性反流一致。11 名有吸入高风险的婴儿接受了手术干预。除 1 名外，所有婴儿的 pH 评分均为阴性，而 10/11 名婴儿的加速度计检测为阳性。