Division of Neonatology, Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI, USA.
J Perinatol. 2021 Aug;41(8):1879-1885. doi: 10.1038/s41372-021-01034-5. Epub 2021 Mar 23.
To evaluate the clinical usefulness of a non-invasive accelerometric device to diagnose GER in preterm babies.
An accelerometer was taped over the sub-xiphoid process in 110 preterm (GA 29.6 ± 3.3 wk) infants (133 studies). Low frequency, sub-audible signals were captured via digital recording (sampling rate 200 Hz), then re-sampled (rate = 60 Hz) to create a spectrogram (focused range 0-30 Hz). Mean amplitude in the focused range was calculated.
Of 85 studies with simultaneous pH-metry and accelerometry, 18 had concurrent positive and 23 had concurrent negative scores, 42 had negative pH scores when accelerometry was positive (≥1 µV), consistent with non-acid reflux. Eleven infants at high risk of aspiration received surgical interventions. All but 1 had negative pH scores while 10/11 had positive accelerometry.
The non-invasiveness of this accelerometric technique allows for GER screening and for repeated testing to assess efficacy of interventions.
评估一种非侵入性加速计设备在诊断早产儿胃食管反流（GER）中的临床应用价值。
将加速度计贴在 110 名早产儿（GA 29.6±3.3 周）的剑突下（SUB），共进行了 133 次研究。通过数字记录（采样率 200Hz）捕获低频、次声信号，然后重新采样（速率=60Hz）以创建频谱图（聚焦范围 0-30Hz）。计算聚焦范围内的平均幅度。
在 85 项同时进行 pH 测量和加速度计检测的研究中，18 项同时存在阳性和 23 项同时存在阴性评分，42 项当加速度计阳性（≥1µV）时 pH 评分阴性，与非酸性反流一致。11 名有吸入高风险的婴儿接受了手术干预。除 1 名外，所有婴儿的 pH 评分均为阴性，而 10/11 名婴儿的加速度计检测为阳性。
这种非侵入性的加速计技术允许进行 GER 筛查和重复测试以评估干预措施的疗效。
