Zhao Weizhu, Yang Haiying, Chai Jie, Xing Ligang
Department of Radiology, Cancer Hospital Affiliated to Shandong First Medical University, Shandong Cancer Hospital and Institute, Jinan, 250117, People's Republic of China.
Department of Oncology, Binzhou People's Hospital, Binzhou, 256610, People's Republic of China.
Cancer Manag Res. 2021 Mar 16;13:2539-2548. doi: 10.2147/CMAR.S302173. eCollection 2021.
The transcription factor runt-related protein 2 (RUNX2) has an important impact on the transformation of bone marrow mesenchymal stem cells to osteoblasts. Further studies have shown that RUNX2 plays a key role in the invasion and metastasis of cancers. RUNX2 is a "key" molecule in the regulatory network comprised of multiple signaling pathways upstream and its target downstream molecules. Due to the complex regulatory mechanisms of RUNX2, the specific mechanism underlying the occurrence, development and prognosis of malignant tumors has not been fully understood. Currently, RUNX2 as a promising therapeutic target for cancers has become a research hotspot. Herein, we reviewed the current literature on the modulatory functions and mechanisms of RUNX2 in the development of malignant tumors, aiming to explore its potential clinical application in the diagnosis, prognosis and treatment of tumors.
转录因子 runt 相关蛋白 2（RUNX2）对骨髓间充质干细胞向成骨细胞的转化具有重要影响。进一步研究表明，RUNX2 在癌症的侵袭和转移中起关键作用。RUNX2 是由上游多个信号通路及其下游靶分子组成的调控网络中的“关键”分子。由于 RUNX2 的调控机制复杂，恶性肿瘤发生、发展及预后的具体机制尚未完全明确。目前，RUNX2 作为一种有前景的癌症治疗靶点已成为研究热点。在此，我们综述了当前关于 RUNX2 在恶性肿瘤发生发展中的调节功能及机制的文献，旨在探索其在肿瘤诊断、预后及治疗中的潜在临床应用。
