Department of Biotechnology, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
Curr Protein Pept Sci. 2021;22(7):534-547. doi: 10.2174/1389203721666201116115337.
As a major threat among women globally, breast cancer (BC) emerges as a primary research focus for several researchers. Although various therapeutic regimens are available, there is an increased chance of metastasis of BC cells, which raises the severity of this malignancy. Of multiple preferred secondary targets, metastasis to bone is extensively studied. Besides deemed as a bone transcription factor, Runx2 also acts as a metastatic factor that promotes growth and metastasis of BC cells. Studies have reported the significant role of microRNAs (miRNAs) in BC pathogenesis and metastasis by governing Runx2 expression. Additionally, dysregulation of the signaling pathways, including Wnt/β-catenin, TGF-β, Notch, and PI3K/AKT, has been observed to influence the expression of Runx2 in BC cells. In this review, we have aimed to highlight the regulatory role of miRNAs in targeting Runx2 both directly and indirectly by governing respective signaling pathways during bone metastasis of BC.
作为全球女性的主要威胁之一，乳腺癌（BC）成为许多研究人员的主要研究焦点。尽管有多种治疗方案可用，但 BC 细胞转移的机会增加了，这增加了这种恶性肿瘤的严重性。在多个首选的次要靶标中，转移到骨骼得到了广泛研究。Runx2 不仅被认为是一种骨转录因子，还作为一种促进 BC 细胞生长和转移的转移因子。研究表明，microRNAs（miRNAs）通过调控 Runx2 的表达在 BC 的发病机制和转移中发挥重要作用。此外，包括 Wnt/β-catenin、TGF-β、Notch 和 PI3K/AKT 在内的信号通路的失调也被观察到会影响 BC 细胞中 Runx2 的表达。在这篇综述中，我们旨在强调 miRNA 通过调控各自的信号通路，直接和间接地调控 Runx2 的表达，从而在 BC 的骨骼转移中发挥重要作用。
