Song Danyang, Liu Hao, Wu Jian, Gao Xiaoliang, Hao Jianyu, Fan Daiming
Department of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Military Medical University, Xi'an 710032, China.
J Cancer. 2021 Mar 1;12(8):2456-2464. doi: 10.7150/jca.48707. eCollection 2021.
Endoplasmic reticulum resident protein 57 (ERp57) has a molecular weight of 57 kDa, belongs to the protein disulfide-isomerase (PDI) family, and is primarily located in the endoplasmic reticulum (ER). ERp57 functions in the quality control of nascent synthesized glycoproteins, participates in major histocompatibility complex (MHC) class I molecule assembly, regulates immune responses, maintains immunogenic cell death (ICD), regulates the unfolded protein response (UPR), functions as a 1,25-dihydroxy vitamin D (1,25(OH)D) receptor, regulates the NF-κB and STAT3 pathways, and participates in DNA repair processes and cytoskeletal remodeling. Recent studies have reported ERp57 overexpression in various human cancers, and altered expression and aberrant functionality of ERp57 are associated with cancer growth and progression and changes in the chemosensitivity of cancers. ERp57 may become a potential biomarker and therapeutic target to combat cancer development and chemoresistance. Here, we summarize the available knowledge of the role of ERp57 in cancer and the underlying mechanisms.
内质网驻留蛋白57（ERp57）分子量为57 kDa，属于蛋白质二硫键异构酶（PDI）家族，主要位于内质网（ER）。ERp57在新生合成糖蛋白的质量控制中发挥作用，参与主要组织相容性复合体（MHC）I类分子组装，调节免疫反应，维持免疫原性细胞死亡（ICD），调节未折叠蛋白反应（UPR），作为1,25 - 二羟基维生素D（1,25(OH)D）受体发挥作用，调节NF - κB和STAT3信号通路，并参与DNA修复过程和细胞骨架重塑。最近的研究报道了ERp57在多种人类癌症中的过表达，且ERp57表达的改变和功能异常与癌症生长、进展以及癌症化疗敏感性的变化有关。ERp57可能成为对抗癌症发展和化疗耐药性的潜在生物标志物和治疗靶点。在此，我们总结了关于ERp57在癌症中的作用及潜在机制的现有知识。
