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挥鞭伤后多发性硬化症的诊断：是否存在真正的关联？

A Diagnosis of Multiple Sclerosis Following Whiplash Injury: Is There a True Association?

作者信息

Harris Lauren, Hateley Sofie, Baheerathan Aravindhan, Malik Omar

机构信息

Neuroscience, Imperial College Healthcare National Health Service Trust, London, GBR.

Neurology, Imperial College Healthcare National Health Service Trust, London, GBR.

出版信息

Cureus. 2021 Feb 18;13(2):e13411. doi: 10.7759/cureus.13411.

DOI:10.7759/cureus.13411
PMID:33758706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7980313/
Abstract

We report a case of a previously well, 25-year-old Caucasian female whose diagnosis of multiple sclerosis (MS) followed significant trauma. Her symptoms and signs developed quickly and satisfied the criteria for rapidly evolving relapsing-remitting MS. She was started on natalizumab (Tysabri) and was stabilized. We discuss the existing literature on traumatic demyelination and possible underlying mechanisms.

摘要

我们报告了一例既往健康的25岁白种女性病例，其在遭受严重创伤后被诊断为多发性硬化症（MS）。她的症状和体征迅速出现，符合快速进展型复发缓解型MS的标准。她开始使用那他珠单抗（泰萨比）治疗并病情稳定。我们讨论了关于创伤性脱髓鞘的现有文献及可能的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a8/7980313/f26fe5679b86/cureus-0013-00000013411-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a8/7980313/774513689b2c/cureus-0013-00000013411-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a8/7980313/c53b482ab11d/cureus-0013-00000013411-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a8/7980313/f26fe5679b86/cureus-0013-00000013411-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a8/7980313/774513689b2c/cureus-0013-00000013411-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a8/7980313/c53b482ab11d/cureus-0013-00000013411-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46a8/7980313/f26fe5679b86/cureus-0013-00000013411-i03.jpg

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1
A Diagnosis of Multiple Sclerosis Following Whiplash Injury: Is There a True Association?挥鞭伤后多发性硬化症的诊断：是否存在真正的关联？
Cureus. 2021 Feb 18;13(2):e13411. doi: 10.7759/cureus.13411.
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Emergence of rheumatoid arthritis following exposure to natalizumab.依那西普治疗类风湿关节炎的安全性研究
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Biomarkers identification for PML monitoring, during Natalizumab (Tysabri®) treatment in Relapsing-Remitting Multiple Sclerosis.用于监测帕利珠单抗（natalizumab）（特立氟胺）治疗复发缓解型多发性硬化症期间 PML 的生物标志物鉴定。
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Natalizumab is Effective for the Treatment of Relapsing-remitting Tumefactive Multiple Sclerosis.那他珠单抗对复发缓解型瘤样多发性硬化症的治疗有效。
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Natalizumab (Tysabri) treatment for relapsing multiple sclerosis.那他珠单抗（泰萨比）治疗复发型多发性硬化症。
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Gynecological adverse effects of natalizumab administration: Case report and review of the literature.纳武利尤单抗治疗的妇科不良反应：病例报告及文献复习。
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Case Rep Oncol. 2019 Jan 18;12(1):59-62. doi: 10.1159/000496198. eCollection 2019 Jan-Apr.

本文引用的文献

1
Sympathetic Ophthalmia.交感性眼炎
Ocul Immunol Inflamm. 2017 Apr;25(2):149-151. doi: 10.1080/09273948.2017.1305727.
2
Spinal cord injury is related to an increased risk of multiple sclerosis: a population-based, propensity score-matched, longitudinal follow-up study.脊髓损伤与多发性硬化症风险增加相关：一项基于人群的倾向评分匹配纵向随访研究。
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Trauma to the central nervous system may result in formation or enlargement of multiple sclerosis plaques.中枢神经系统创伤可能导致多发性硬化斑块的形成或扩大。
Arch Neurol. 2000 Jul;57(7):1074-7, discussion 1078. doi: 10.1001/archneur.57.7.1074.
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Neurology. 2000 Mar 28;54(6):1393; author reply 1394-5.
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Neurology. 1999 Jun 10;52(9):1737-45. doi: 10.1212/wnl.52.9.1737.
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Concept of autoimmunity following spinal cord injury: possible roles for T lymphocytes in the traumatized central nervous system.脊髓损伤后自身免疫的概念：T淋巴细胞在创伤性中枢神经系统中的可能作用。
J Neurosci Res. 1996 Aug 15;45(4):349-63. doi: 10.1002/(SICI)1097-4547(19960815)45:4<349::AID-JNR4>3.0.CO;2-9.
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The role of trauma in the pathogenesis of multiple sclerosis: a review.创伤在多发性硬化症发病机制中的作用：综述
Clin Neurol Neurosurg. 1994 May;96(2):103-10. doi: 10.1016/0303-8467(94)90042-6.