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[影响某地区创伤中心髋部骨折患者死亡率的危险因素]

[Risk factors affecting mortality in patients with hip fractures at a regional trauma center].

作者信息

Darwich Ali, Assaf Elio, Klein Roman, Gravius Sascha, Wölfl Christoph G, Jawhar Ahmed

机构信息

Orthopädisch-Unfallchirurgisches Zentrum, Medizinische Fakultät Mannheim der Universität Heidelberg, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

Klinik für Orthopädie, Unfallchirurgie und Sporttraumatologie, Marienhausklinikum Hetzelstift, Stiftstraße  10, 67434, Neustadt/Weinstraße, Deutschland.

出版信息

Z Gerontol Geriatr. 2021 Oct;54(6):561-570. doi: 10.1007/s00391-021-01869-9. Epub 2021 Mar 23.

Abstract

BACKGROUND

Primary care hospitals and regional trauma centers play an essential role in the treatment of hip fractures.

OBJECTIVE

This study investigated the relationship between patient-related parameters and in-hospital mortality as well as complications of hip fractures at a regional trauma center.

METHODS

In a retrospective study, data were collected from all patients > 60 years admitted over 2 years to a regional trauma center with a hip fracture. Patient-related parameters included age, sex, fracture location, method of surgical treatment, time of surgery, duration of surgery, length of inpatient stay, blood transfusion, complications, comorbidities, use of anticoagulant medication and need for postoperative intensive care treatment. The relationship between these parameters and hospital mortality as well as complications was investigated.

RESULTS

Data were collected from 360 patients undergoing 335 surgeries (f:m 225:110) with a mean age of 83 ± 8 years. The total in-hospital mortality rate was 7.76% (n = 26). Factors increasing in-hospital mortality included: age > 85 years (odds ratio [OR] 5.126; 95% confidence interval [CI] 0.665-39.498; p = 0.1167); male sex (OR 1.85 95%-CI [0.82-4.14]; p = 0.0555); time of surgery > 24 h (OR 1.896 95%-CI [0.661-5.441]; p = 0.2341); ≥ 3 comorbidities (OR 10.61 95%-CI [3.681-27.501]; p < 0.0001); intake of anticoagulants (OR 6.19 95%-CI [2.69-14.24]; p < 0.0001) and postoperative intensive care (OR 5.9 95%-CI [2.56-13.76]; p < 0.0001).

CONCLUSION

In the present study a statistically significant influence of the number of comorbidities or Charlson comorbidity index, the intake of anticoagulant drugs and need for postoperative intensive care treatment on the in-hospital mortality of patients with proximal femoral fractures in a regional trauma center was found.

摘要

背景

基层医疗医院和区域创伤中心在髋部骨折治疗中发挥着重要作用。

目的

本研究调查了区域创伤中心患者相关参数与髋部骨折住院死亡率及并发症之间的关系。

方法

在一项回顾性研究中,收集了2年内入住某区域创伤中心且年龄大于60岁的所有髋部骨折患者的数据。患者相关参数包括年龄、性别、骨折部位、手术治疗方法、手术时间、手术时长、住院时间、输血情况、并发症、合并症、抗凝药物使用情况以及术后重症监护治疗需求。研究了这些参数与医院死亡率及并发症之间的关系。

结果

收集了360例接受335次手术患者的数据(女性:男性为225:110),平均年龄83±8岁。总住院死亡率为7.76%(n = 26)。增加住院死亡率的因素包括:年龄大于85岁(比值比[OR] 5.126;95%置信区间[CI] 0.665 - 39.498;p = 0.1167);男性(OR 1.85;95% CI [0.82 - 4.14];p = 0.0555);手术时间大于24小时(OR 1.896;95% CI [0.661 - 5.441];p = 0.2341);≥3种合并症(OR 10.61;95% CI [3.681 - 27.501];p < 0.0001);服用抗凝剂(OR 6.19;95% CI [2.69 - 14.24];p < 0.0001)以及术后重症监护(OR 5.9;95% CI [2.56 - 13.76];p < 0.0001)。

结论

在本研究中,发现区域创伤中心股骨近端骨折患者的合并症数量或查尔森合并症指数、抗凝药物的服用以及术后重症监护治疗需求对住院死亡率有统计学上的显著影响。

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本文引用的文献

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Use of Anticoagulants Remains a Significant Threat to Timely Hip Fracture Surgery.使用抗凝剂仍然是及时进行髋部骨折手术的重大威胁。
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