Department of Clinical Sciences and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, UK.
Liphook Equine Hospital, Liphook, Hampshire, UK.
Vet Rec. 2021 Jul;189(1):e142. doi: 10.1002/vetr.142. Epub 2021 Mar 23.
Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control have not been previously investigated.
Clinical records were searched to identify the sample of animals with PPID treated with pergolide from 2016 to 2019. The signalment was noted and the dose of pergolide received calculated. Animals were classified as compliant (receiving ≥90% of the veterinarian recommended dose of pergolide) or non-compliant, and as controlled (follow-up basal adrenocorticotrophic hormone concentrations within the reference range) or not.
In total, 110 animals were included. The majority (85%) were ≥16 years (mean ± SD 19.8 ± 4.4 years); the most common breeds were Cob (18%), Thoroughbred (16%) and Welsh (15%); 37% were female and 63% male. Overall, 48% were compliant and 52% non-compliant. There was no significant effect of compliance on laboratory control. Of those that were compliant, 74% were controlled, while 67% of non-compliant animals were controlled. Univariable analysis revealed a significant (p < 0.001) effect of age and breed on compliance and control, and of sex on control. On multivariable analysis, only age (compliance) and breed (compliance and control) were retained in the final model.
Only half of animals received the recommended pergolide dose; however, this did not affect laboratory control of PPID.
马属动物脑垂体中间叶功能减退症（PPID）采用每日培高利特治疗。此前尚未对主人的依从性及其对 PPID 控制的影响进行研究。
检索临床记录，以确定 2016 年至 2019 年期间接受培高利特治疗的患有 PPID 的动物样本。记录了动物的特征，并计算了培高利特的剂量。将动物分为依从性（接受兽医推荐剂量的培高利特≥90%）或不依从性，以及控制性（随访基础促肾上腺皮质激素浓度在参考范围内）或非控制性。
共纳入 110 例动物。大多数（85%）年龄≥16 岁（平均±标准差 19.8±4.4 岁）；最常见的品种为考比马（18%）、纯血马（16%）和威尔士马（15%）；37%为雌性，63%为雄性。总体而言，48%的动物为依从性，52%的动物为不依从性。依从性对实验室控制无显著影响。在依从性的动物中，74%的动物得到控制，而非依从性动物中，67%的动物得到控制。单变量分析显示，年龄和品种对依从性和控制有显著影响（p<0.001），而性别对控制有显著影响。多变量分析显示，仅年龄（依从性）和品种（依从性和控制）保留在最终模型中。
只有一半的动物接受了推荐的培高利特剂量；然而，这并未影响 PPID 的实验室控制。
