2017-2019 年中国新发病例和复治肺结核患者中耐药结核分枝杆菌分离株。
Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019.
机构信息
Zhejiang University, College of Medicine, The First Affiliated Hospital, Department of Pathology, Hangzhou, Zhejiang, China.
Hangzhou Center for Disease Control and Prevention, Department of TB Control and Prevention, Hangzhou, Zhejiang, China.
出版信息
Rev Soc Bras Med Trop. 2021 Mar 22;54:e0728-2020. doi: 10.1590/0037-8682-0728-2020. eCollection 2021.
INTRODUCTION
Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.
METHODS
MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.
RESULTS
Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).
CONCLUSIONS
The proportion of mono-SM-resistant TB among new patients was higher.
简介
结核分枝杆菌（MTB）是导致全球范围内结核病（TB）的病原体。
方法
对 MTB 进行表型药物敏感性试验（DST），并对耐药基因进行测序。
结果
既往治疗过的患者更可能出现阳性涂片结果并表现出耐药性。新患者更可能是单耐药 SM，不太可能是 INH 和 RIF 耐药。最常见的突变是 katG（S315T）、rpoB（S450L）、rpsL（K43R）和 embB（M306V）。
结论
新患者中单耐药 SM 的比例更高。
Zotero 插件