Medical Research Institute, Mackenzie Evangelical School of Paraná, Curitiba, PR, Brazil.
Evangelical Mackenzie University Hospital, Curitiba, Paraná, Brazil.
Arq Bras Cir Dig. 2021 Mar 22;33(4):e1569. doi: 10.1590/0102-672020200004e1569. eCollection 2021.
OPN ABCB5. Studies with biomarkers in TMA (tissue microarray) have been showing important results regarding its expression in colon cancer.
Correlate the expression profile of the OPN and ABCB5 biomarkers with the epidemiological and clinicopathological characteristics of the patients, the impact on the progression of the disease and the death.
A total of 122 CRC patients who underwent surgical resection, immunomarking and their relationship with progression and death events were evaluated.
The average age was 61.9 (±13.4) years. The cases were distributed in 42 (35.9%) in the ascending/transverse colon, 31 (26.5%) in the sigmoid, 27 in the rectum (23.1%), 17 (14.5%) in the descending colon. Most patients had advanced disease (stages III and IV) in 74 cases (60.9%). There was a predominance of moderately differentiated tumors in 101 samples (82.8%); despite this, the poorly differentiated subtype proved to be an independent risk factor for death in 70%. Metastasis to the liver proved to be an independent risk factor for death in 75% (18/24), as well as patients with primary rectal tumors in 81.5% (22/27).
The immunohistochemical expression of the OPN and ABCB5 markers was not associated with epidemiological and clinicopathological characteristics. Regarding the progression of disease and death, it was not possible to observe a correspondence relationship with the evaluated markers.
OPN ABCB5。使用 TMA（组织微阵列）中的生物标志物进行的研究已经显示出其在结肠癌中的表达的重要结果。
将 OPN 和 ABCB5 生物标志物的表达谱与患者的流行病学和临床病理特征相关联，评估其对疾病进展和死亡的影响。
对 122 例接受手术切除、免疫标记和评估其与疾病进展和死亡事件的关系的 CRC 患者进行了研究。
患者的平均年龄为 61.9（±13.4）岁。病例分布在升结肠/横结肠 42 例（35.9%），乙状结肠 31 例（26.5%），直肠 27 例（23.1%），降结肠 17 例（14.5%）。74 例（60.9%）患者患有晚期疾病（III 期和 IV 期）。101 例（82.8%）为中度分化肿瘤，尽管如此，低分化亚型被证明是 70%死亡的独立危险因素。肝转移被证明是 75%（18/24）死亡的独立危险因素，直肠原发肿瘤患者的死亡率为 81.5%（22/27）。
OPN 和 ABCB5 标志物的免疫组织化学表达与流行病学和临床病理特征无关。关于疾病进展和死亡，无法观察到与评估标志物之间的对应关系。
