Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Ciências e Tecnologia, Departamento de Fisioterapia, Presidente Prudente, São Paulo, Brazil.
Oxford Brookes University, Faculty of Health and Life Sciences, Department of Biological and Medical Sciences, Oxford, United Kingdom.
Arq Neuropsiquiatr. 2021 Feb;79(2):114-121. doi: 10.1590/0004-282X-anp-2020-0088.
Parkinson's disease (PD) produces autonomic changes, indicating lower parasympathetic modulation and global variability, but these changes need further studying regarding geometric methods.
To investigate the autonomic modulation in individuals with PD using heart rate variability (HRV) indices obtained through geometric methods.
This is a cross-sectional study that assessed 50 individuals, split into two groups: PD group (PDG; n=26; 75.36±5.21 years) and control group (CG; n=24; 75.36±5.21 years). We evaluated the autonomic modulation by measuring the heart rate beat-to-beat for 30 min with the individual in supine rest using a heart rate monitor and assessed geometric indices (RRtri, TINN, SD1, SD2, SD1/SD2 ratio, and qualitative analysis of the Poincaré plot).
Significant reductions were found in RRtri, TINN, SD1, and SD2 indices among PDG compared to CG. Regarding the SD1/SD2 ratio, no significant changes were detected between the groups. The Poincaré plot demonstrated that individuals with PD had lower beat-to-beat dispersion in RR intervals, in addition to greater long-term dispersion of RR intervals compared to CG.
The results suggest a reduction in the parasympathetic autonomic modulation and global variability in individuals with PD compared to controls, regardless of sex, age, and body mass index.
帕金森病（PD）会产生自主神经变化，表明副交感神经调节降低和整体可变性降低，但这些变化需要进一步研究几何方法。
使用通过几何方法获得的心率变异性（HRV）指数来研究 PD 患者的自主神经调节。
这是一项横断面研究，评估了 50 名个体，分为两组：PD 组（PDG；n=26；75.36±5.21 岁）和对照组（CG；n=24；75.36±5.21 岁）。我们通过使用心率监测器让个体在仰卧休息时记录 30 分钟的心率跳动来评估自主神经调节，并评估几何指数（RRtri、TINN、SD1、SD2、SD1/SD2 比值和 Poincaré 图的定性分析）。
与 CG 相比，PDG 的 RRtri、TINN、SD1 和 SD2 指数显著降低。关于 SD1/SD2 比值，两组之间没有发现显著变化。Poincaré 图表明，与 CG 相比，PD 患者的 RR 间期的心率跳动离散度更低，RR 间期的长期离散度更大。
与对照组相比，无论性别、年龄和体重指数如何，PD 患者的副交感自主神经调节和整体可变性均降低。
