Segev Lee, Maymon Ron, Mihailovici Anca, Gordin Kopylov Lital
Department of Obstetrics and Gynecology, The Yitzhak Shamir Medical Center (formerly Assaf Harofeh Medical Center), Zerifin, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Harefuah. 2021 Feb;160(2):81-86.
The study aimed to assess the fetal heart defects that led to termination of pregnancy (TOP), the weeks' gestation that the defect was first diagnosed, whether TOP was conducted and the timeline of events that led to the decision. This is in order to encourage pregnant women to conduct sonographic screening tests that are recommended during pregnancy.
All pregnant women with singleton pregnancy who underwent TOP in our institute because of fetal heart defects as an only finding between 2000-2017 were included. TOPs preformed because of multisystem defects, abnormal karyotype and chromosomal or genetic defect were excluded. The patients were stratified into late TOP (≥24 weeks' gestation) and early TOP (<24 weeks' gestation).
There were 3469 TOP and 228 (6.5%) cases because of fetal heart defects as the only abnormal finding. Of these cases, 191 (83.7%) and 37 (16.3%) were conducted before and after 24 weeks' gestation respectively. The mean weeks' gestation during which the heart defect was first diagnosed and TOP was conducted was 18.7±4.1 and 20.6± 3.7 respectively. The single most common heart defect was of the ventricular outflow tract that was found in 102 cases (44.7%), followed by functionally univentricular heart in 79 cases (34.6%). A combination of two defects was found in 5 cases (2.2%) and was mostly diagnosed after 24 weeks' gestation. Out of all cases 16.8% did not go through early fetal anomaly scan (conducted between 14-16 weeks' gestation), compared to 66.7% of late TOP cases; 22.2% of cases were not diagnosed during routine anomaly scans.
In most cases the fetal heart defect was diagnosed during routine 14-16 gestational weeks anomaly scan.
This information should encourage pregnant women to perform timely sonographic scanning.
本研究旨在评估导致妊娠终止(TOP)的胎儿心脏缺陷、首次诊断出缺陷时的孕周、是否进行了妊娠终止以及导致该决定的事件时间线。这是为了鼓励孕妇进行孕期推荐的超声筛查检查。
纳入2000年至2017年间在我院因胎儿心脏缺陷作为唯一发现而接受TOP的所有单胎妊娠孕妇。因多系统缺陷、异常核型以及染色体或基因缺陷而进行的TOP被排除。患者被分为晚期TOP(≥24周妊娠)和早期TOP(<24周妊娠)。
共有3469例TOP,其中228例(6.5%)是因胎儿心脏缺陷作为唯一异常发现。在这些病例中,分别有191例(83.7%)和37例(16.3%)在24周妊娠之前和之后进行。首次诊断出心脏缺陷和进行TOP时的平均孕周分别为18.7±4.1周和20.6±3.7周。最常见的单一心脏缺陷是心室流出道缺陷,共102例(44.7%),其次是功能性单心室心脏,79例(34.6%)。5例(2.2%)发现有两种缺陷组合,大多在24周妊娠后被诊断。在所有病例中,16.8%未进行早期胎儿异常扫描(在14至16周妊娠期间进行),而晚期TOP病例中这一比例为66.7%;22.2%的病例在常规异常扫描期间未被诊断。
在大多数情况下,胎儿心脏缺陷是在常规妊娠14至16周异常扫描期间被诊断出来的。
这些信息应鼓励孕妇及时进行超声扫描。