二甲双胍对肥胖或超重青少年减肥有效吗？

Is metformin effective for reducing weight in obese or overweight adolescents?

机构信息

Valley Family Medicine Residency, University of Washington at Valley, Renton, USA.

Health Sciences Librarian Emeritus, University of Washington Medical School, Seattle, USA.

出版信息

J Fam Pract. 2021 Mar;70(2):100-101. doi: 10.12788/jfp.0158.

DOI:10.12788/jfp.0158

PMID:33760905

Abstract

YES, TO SOME DEGREE-BUT IT IS OF UNCERTAIN CLINICAL SIGNIFICANCE. OVER A PERIOD OF 6 MONTHS, METFORMIN MODESTLY REDUCED WEIGHT (-2.1 KG) AND BODY FAT MASS (-1.9%), BUT NOT BODY MASS INDEX (BMI) OR LEAN BODY MASS, IN ADOLESCENTS WHO WERE OVERWEIGHT OR OBESE. THIS IS COMPARABLE TO LIFESTYLE INTERVENTIONS (DIET AND EXERCISE) SUPPORTED WITH > 26 HOURS OF COUNSELING, WHICH MODESTLY IMPROVED BMI BUT NOT WEIGHT. (STRENGTH OF RECOMMENDATION [SOR]: A, BASED ON A LARGE META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS [RCTS] OF VARIABLE QUALITY).

摘要

是的，在一定程度上是这样——但这具有不确定的临床意义。在 6 个月的时间里，二甲双胍适度减轻了超重或肥胖青少年的体重（-2.1 公斤）和体脂量（-1.9%），但没有减轻体重指数（BMI）或去脂体重。这与生活方式干预（饮食和运动）相当，生活方式干预支持超过 26 小时的咨询，适度改善了 BMI，但没有减轻体重。（推荐强度[SOR]：基于对 RCT 进行的大型荟萃分析[A]，RCT 质量存在差异）。